Skip Navigation LinksHome > May 2014 - Volume 41 - Issue 5 > High-Dose Vaginal Maintenance Metronidazole for Recurrent Ba...
Sexually Transmitted Diseases:
doi: 10.1097/OLQ.0000000000000123
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High-Dose Vaginal Maintenance Metronidazole for Recurrent Bacterial Vaginosis: A Pilot Study

Aguin, Tina MD*; Akins, Robert A. PhD; Sobel, Jack D. MD

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Abstract

The purpose of this study was to explore the benefit of high-dose intravaginal metronidazole as a maintenance therapy in reducing recurrence rates of bacterial vaginosis (BV).Eighteen women with a history of recurrent BV and symptomatic BV were treated with metronidazole 750 mg suppository intravaginally daily for 7 days. Those in remission by Amsel criteria received metronidazole 750 mg twice weekly for 3 months with further follow-up for 3 months. High-dose metronidazole intravaginally was associated with rare clinical recurrence during the period of use. After cessation of suppression therapy, recurrence was high.

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