Abstract: Our review of Neisseria gonorrhoeae pharyngeal treatment failures from sexually transmitted infection clinics in Alberta suggests that treatment failures with oral cefixime monotherapy were not related to elevated cefixime minimum inhibitory concentrations. Dual therapy with oral cefixime and azithromycin may be a suitable alternate for the treatment of pharyngeal gonorrhea.
Our review of Neisseria gonorrhoeae pharyngeal treatment failures from sexually transmitted infection clinics in Alberta suggests that dual therapy with oral cefixime and azithromycin may be a suitable alternate for pharyngeal gonorrhea.
From the *STI Services, Alberta Health Services (AHS), Edmonton, Canada; †STI Clinic, AHS, Edmonton, Canada; ‡STI Clinic, AHS, Calgary, Canada; and §Provincial Laboratory for Public Health, AHS, Calgary, Canada
Acknowledgments: The authors wish to acknowledge the extraction of laboratory data by M. Lovgren, sequencing done at ProvLab Alberta (K. Pabbaraju, S. Wong, J. Song, K. Gill, K. Chow, A. Wong), and manuscript review by the Alberta Gonorrhea Antimicrobial Surveillance Working Group (M. Lovgren, B. Romanowski, K. Simmonds, K. Sutherland, J. Talbot, R. Verity, and K. Zhang).
Funding: This work was supported by the Provincial Laboratory of Public Health’s summer studentship program and as part of a ProvLab program enhancement to Steven Drews.
The authors have declared no conflict of interest.
Declarations: Preliminary data from this project were presented as a poster at ID Week, San Diego, CA; October 17–21, 2012: Gratrix J, Bergman J, Read R, Lovgren M, Drews S, Singh AE. A retrospective review of pharyngeal gonorrhea clinical failures to cefixime in two STI clinics in Alberta, Canada.
Correspondence: Ameeta E. Singh, BMBS (UK), MSc, FRCPC, Alberta Health Services – Edmonton STI Clinic, 3B20-11111 Jasper Ave, Edmonton, AB. T5K0L4. E-mail: firstname.lastname@example.org.
Received for publication June 21, 2013, and accepted August 19, 2013.