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Sexually Transmitted Diseases:
doi: 10.1097/OLQ.0000000000000036
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Effect of Multiple Freeze and Thaw Cycles on the Sensitivity of IgG and IgM Immunoglobulins in the Sera of Patients With Syphilis

Castro, Arnold R. PhD; Jost, Heather A. BS

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Abstract

We describe the effects of multiple freeze and thaw cycles on the sensitivity of the immunoglobulins IgG and IgM measured by enzyme-linked immunoassays in the sera of patients with syphilis. Stored frozen sera can withstand repeated freezing and thawing cycles with a minimal detrimental effect on the sensitivity of the sera.

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