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Molecular Subtyping of Treponema pallidum in Paris, France

Grange, Philippe Alain PhD*; Allix-Beguec, Caroline PhD; Chanal, Johan MD*‡; Benhaddou, Nadjet MD§; Gerhardt, Philippe MD; Morini, Jean-Pierre MD; Deleuze, Jean MD; Lassau, François MD; Janier, Michel MD; Dupin, Nicolas MD*‡

doi: 10.1097/OLQ.0000000000000006

Two major Treponema pallidum subtypes, 14 d/g and 14 d/f, were identified in a population of 119 patients with syphilis in Paris, France, characterized by a high proportion of men who have sex with men. A new subtype named 11 q/j was characterized, and a reinfection case was determined in 1 patient having consecuitve syphilis infection at 19-month interval.

This epidemiological study of Treponema pallidum strains has shown a low genetic variation with the 14 d/g subtype predominating in the men who have sex with men population in Paris, France.

From the *Laboratoire de Recherche en Dermatologie, EA 1833, Centre National de Référence Syphilis, Faculté de Médecine, Université Sorbonne Paris Descartes, Paris, France; †Genoscreen, Lille, France; ‡Service de Dermatologie-Vénéréologie, Hôpital Cochin, Pavillon Tarnier, APHP, Paris, France; §Service de Bactériologie, Groupe Hospitalier Paris Centre Cochin-Hôtel Dieu-Broca, Paris, France; and ¶Centre des MST, Hôpital Saint-Louis, APHP, Paris, France

Acknowledgment: The authors thank Soline Dhauteville for technical supports and all the nurses of the sexually transmitted disease unit and Frédérique De Matos for the molecular analysis. This work was supported by the Institut National de Veille Sanitaire, the Société Française de Dermatologie, and the Association de Recherche en Virologie et Dermatologie.

Conflicts of interest and source of funding: None declared.

Correspondence: Nicolas Dupin, MD, Hôpital Cochin, Pavillon Tarnier, Laboratoire de Recherche en Dermatologie, UPRES EA 1833 et CNR Syphilis, 89, rue d’Assas, 75006 Paris, France. E-mail:

Received for publication January 28, 2013, and accepted April 30, 2013.

© Copyright 2013 American Sexually Transmitted Diseases Association