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High-Resolution Typing Reveals Distinct Chlamydia trachomatis Strains in an At-Risk Population in Nanjing, China

Bom, Reinier J.M. MSc*; van den Hoek, Anneke MD, PhD†‡; Wang, Qianqiu MD, PhD§¶; Long, Fuquan MD§¶; de Vries, Henry J.C. MD, PhD‡∥**††; Bruisten, Sylvia M. PhD*‡

doi: 10.1097/01.OLQ.0000431355.73217.df
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Abstract: We investigated Chlamydia trachomatis strains from Nanjing, China, and whether these strains differed from Amsterdam, the Netherlands. C. trachomatis type was determined with multilocus sequence typing. Most strains were specific to Nanjing, but some clustered with strains from Amsterdam. This demonstrates a geographical variation in C. trachomatis previously left undetected.

High-resolution typing revealed distinct Chlamydia trachomatis strains in China. This demonstrates the existence of a geographical variation in C. trachomatis strains previously left undetected when only using ompA genovar typing.

From the *Public Health Laboratory and †Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands; ‡Center for Infections and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; §National Center for STD Control, China CDC, Nanjing, China; ¶Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, China ∥STI Outpatient Clinic, Public Health Service of Amsterdam, Amsterdam, the Netherlands; **Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; and ††Center for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, the Netherlands

Acknowledgment: The authors thank Michelle Himschoot, Sahare Gashi-Ilazi, and Nadia Nassir Hajipour for their technical assistance and expertise and Claire Buswell for editing the manuscript.

Conflicts of interest and source of funding: None of the authors had any conflict of interest. This work was supported by the Public Health Service of Amsterdam, the Netherlands.

Correspondence: Sylvia M. Bruisten, PhD, Public Health Laboratory, Public Health Service of Amsterdam, Nieuwe Achtergracht 100, 1018 WT Amsterdam, the Netherlands. E-mail: sbruisten@ggd.amsterdam.nl.

Received for publication November 1, 2012, and accepted May 14, 2013.

© Copyright 2013 American Sexually Transmitted Diseases Association