Sexually Transmitted Diseases

Skip Navigation LinksHome > January 2012 - Volume 39 - Issue 1 > Clinical and Virologic Response to Episodic Acyclovir for Ge...
Sexually Transmitted Diseases:
doi: 10.1097/OLQ.0b013e31823b50c6

Clinical and Virologic Response to Episodic Acyclovir for Genital Ulcers Among HIV-1 Seronegative, Herpes Simplex Virus Type 2 Seropositive African Women: A Randomized, Placebo-Controlled Trial

Baeten, Jared M. MD, PhD*†‡; Reid, Stewart E. MD§¶; Delany-Moretlwe, Sinead MD, PhD**; Hughes, James P. PhD††; Wang, Richard S. MS*; Wilcox, Ellen MSW, MPH*; Limbada, Mohammed MD¶; Akpomiemie, Godspower BPharm, MPH**; Corey, Lawrence MD†‡‡§§; Wald, Anna MD, MPH†‡‡‡§§; Celum, Connie MD, MPH*†‡

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In a randomized trial among African women with recurrent genital herpes, episodic acyclovir therapy resulted in modestly greater likelihood of lesion healing (hazard ratio [HR] = 1.48, P = 0.098; mean, 5.1 vs. 6.0 days) and cessation of herpes simplex virus shedding (HR = 1.88, P = 0.008; mean, 3.0 vs. 5.0 days) compared with placebo, similar to results of studies in high-income countries ( registration NCT00808405).

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