Sexually Transmitted Diseases

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Sexually Transmitted Diseases:
doi: 10.1097/OLQ.0b013e3181fc6944
Original Study

Chlamydia trachomatis Genotypes Among Men Who Have Sex With Men in Australia

Twin, Jimmy PhD*†; Moore, Elya E. PhD*†; Garland, Suzanne M. MBBS, MD, FRCPA, FRANZCOG, Ad Eundem, FAChSHM*†‡§; Stevens, Matthew P. PhD*†; Fairley, Christopher K. PhD¶; Donovan, Basil MD, FAFPHM, FAChSHM, FRCPI∥**; Rawlinson, William PhD††; Tabrizi, Sepehr N. PhD*†‡

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Background: Chlamydia trachomatis is a common bacterial sexually transmitted infection in men who have sex with men (MSM), although little is known about its distribution in Australian MSM communities.

Methods: From 2004 to 2008, 612 consecutive C. trachomatis positive anal swab and urine samples were collected for genotyping and quantification from MSM attending 2 sexual health centers (Melbourne and Sydney).

Results: The most common serovars detected were D (35.2%), G (32.7%), and J (17.7%), although these distributions changed significantly by year and city. C. trachomatis infections (2.8%) involved more than 1 serovar and only 1 lymphogranuloma venereum isolate was detected. The majority of serovar strains showed an identical omp1 genotype, with only 7.5% showing genotypic variability. Serovar G infections were not associated with overseas sexual activity; whilst individuals with serovar J were less likely to have had a prior C. trachomatis infection, and with serovar E were those who had prior C. trachomatis infection. Symptoms were present in 68% of urethral infections and 28% anal infections, and were associated with gonorrheal coinfection (13.8%), prior C. trachomatis infection (20.6%) and increasing age. A higher C. trachomatis load was identified in anal samples versus urine (1.48 × 104 genome copies/anal swab; 3.72 × 103 copies/mL urine) and no association was made to concentration including the presence of symptoms and prior C. trachomatis infection.

Conclusions: This is the largest study of C. trachomatis serovars in MSM: it is the first to report C. trachomatis rectal loads, and provides an overview on C. trachomatis serovars and genotypic variants that circulate in Australian MSM communities.

© Copyright 2011 American Sexually Transmitted Diseases Association


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