Sexually Transmitted Diseases

Skip Navigation LinksHome > December 2008 - Volume 35 - Issue 12 > Changes in Sexual Risk Behavior Among Participants in a PrEP...
Sexually Transmitted Diseases:
doi: 10.1097/OLQ.0b013e3181812939

Changes in Sexual Risk Behavior Among Participants in a PrEP HIV Prevention Trial

Guest, Greg PhD*; Shattuck, Dominick MS*; Johnson, Laura MA*; Akumatey, Betty Mphil‡; Kekawo Clarke, Edith Essie MD§; Chen, Pai-Lien PhD†; MacQueen, Kathleen M. PhD*

Collapse Box


Background: One of the concerns raised regarding the introduction of any new HIV-prevention measure, such as PrEP, is the potential for risk disinhibition or sexual risk compensation. The oral tenofovir HIV prevention trial has been the subject of international discussion in this regard.

Methods: This article maps the changes in sexual risk behavior among women participating in the oral tenofovir HIV prevention trial in Ghana. Content-driven, thematic analysis was carried out on qualitative data obtained from in-depth interviews with study participants. Growth curve analysis was the primary method used to document trends over time in self-reported sexual behavior collected monthly.

Results: Overall, the study found that sexual risk behavior did not increase during the trial. Number of sexual partners and rate of unprotected sex acts decreased across the 12-month period of study enrollment. Certain subgroups of women, however, exhibited different growth curves. Data indicate that the HIV prevention counseling associated with the trial was effective.

Conclusions: Counseling during the trial was effective. Different types of counseling and messaging may be needed for different subgroups within a population. These findings also have implications for required sample sizes for future HIV prevention trials where seroconversion is the main outcome.

© Copyright 2008 American Sexually Transmitted Diseases Association


Article Tools


Article Level Metrics