Sexually Transmitted Diseases

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Sexually Transmitted Diseases:
Article

A Randomized, Double-Blind Clinical Trial of Vaginal Acidification versus Placebo for the Treatment of Symptomatic Bacterial Vaginosis

Holley, Robert L. MD*; Richter, Holly E. PhD, MD*; Varner, R. Edward MD*; Pair, Lisa MSN, CRNP*; Schwebke, Jane R. MD†

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Abstract

Background and Objectives: Vaginal acidification has been suggested as a means of normalizing the vaginal flora.

Goal: The purpose of this study was to determine the effectiveness of an acetic acid-based vaginal gel in the treatment of bacterial vaginosis (BV).

Study Design: Forty-four patients with BV were enrolled in a randomized, double-blind clinic trial. Of these, 29 were evaluable. Patients were randomized to receive either 5 mL acetic acid gel (n = 14) or placebo gel (n = 15) intravaginally twice daily for 7 days. Clinical criteria and vaginal Gram stain scores were compared between the initial visit and at 2 weeks after initiating therapy.

Results: No significant differences were noted when comparing drug and placebo in terms of subjective or clinical improvement or improvement in Gram stain smears for bacterial vaginosis.

Conclusion: Vaginal acidification with an acetic acid gel formulated to pH 3.9 to 4.1 was ineffective therapy for bacterial vaginosis.

© Copyright 2004 American Sexually Transmitted Diseases Association

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