Sexually Transmitted Diseases

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Sexually Transmitted Diseases:
Article

Chlamydia trachomatis, Herpes Simplex Virus 2, and Human T-Cell Lymphotrophic Virus Type 1 Are Not Associated With Grade of Cervical Neoplasia in Jamaican Colposcopy Patients

Castle, Philip E. PhD, MPH*; Escoffery, Carlos MD†; Schachter, Julius PhD‡; Rattray, Carole MRCOG, DM, MBBS†; Schiffman, Mark MD, MPH*; Moncada, Jeanne MT‡; Sugai, Karlyn MT‡; Brown, Claudette MPH, FMT†; Cranston, Beverly BSc†; Hanchard, Barrie FRCP(Edin), MBBS, FRCP(C)†; Palefsky, Joel M. MD§; Burk, Robert D. MD∥; Hutchinson, Martha L. MD¶; Strickler, Howard D. MD, MPH*∥

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Abstract

Background: A few recent studies have suggested that other sexually transmitted infections may increase the likelihood of a human papillomavirus (HPV) infection progressing to high-grade cervical neoplasia and cancer.

Goal: The goal was to assess whether exposures to Chlamydia trachomatis, human T-cell lymphotrophic virus type 1 (HTLV-I), and/or human simplex virus type 2 (HSV-2) are greater in colposcopy patients with cervical intraepithelial neoplasia grade 3 or cancer (CIN3+) than in patients with low-grade cervical neoplasia (CIN1).

Study Design: Sequential patients (n = 447) attending a colposcopy clinic in Kingston, Jamaica, a country with high cervical cancer rates and high HTLV-I prevalence, were tested for (1) HPV DNA by L1 consensus primer (MY09/11) polymerase chain reaction assays, (2) C trachomatis DNA by ligase chain reaction, (3) C trachomatis antibodies by both microimmunofluorescence and a peptide (VS4) enzyme linked immunosorbent assay (ELISA), (4) HTLV-I antibodies by ELISA confirmed by western blotting, and (5) HSV-2 antibodies by a recombinant HSV-2-specific ELISA. Odds ratios and 95% confidence intervals were estimated with use of multinomial logistic regression models.

Results: HPV DNA detection was associated with grade of cervical neoplasia but other evaluated sexually transmitted infections were not.

Conclusions: HTLV-I, C trachomatis, and/or HSV-2 were not associated with severity of cervical neoplasia in Jamaican women.

© Copyright 2003 American Sexually Transmitted Diseases Association

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