Sexually Transmitted Diseases

Skip Navigation LinksHome > July 2001 - Volume 28 - Issue 7 > Antenatal Seroprevalence of Herpes Simplex Virus Type 2 (HSV...
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Antenatal Seroprevalence of Herpes Simplex Virus Type 2 (HSV-2) in Canadian Women: HSV-2 Prevalence Increases Throughout the Reproductive Years

PATRICK, DAVID M. MD,FRCPC,MHSc; DAWAR, MEENAKSHI MD,CCFP, FRCPC,MHSc; COOK, DARREL A. MSc; KRAJDEN, MEL MD,FRCPC; NG, HELEN C. BSc,AND; REKART, MICHAEL L. MD,FRCPC,DTM&H

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Abstract

Background: Thisstudy sought to provide the first population estimates of herpes simplex type2 (HSV-2) seroprevalence inCanada.

Goal: Tomeasure the antenatal seroprevalence of HSV-2 antibodies in reproductive agewomen.

StudyDesign: An anonymous unlinked seroprevalence study usedstored sera collected from pregnant women in British Columbia during 1999.Randomized sampling within age strata selected a total of 1215 subjects, ages15 to 44 years. Serologic testing used the Gull Meridian Test. Overallprevalence was directly standardized to the 1999 Canadian femalepopulation.

Results: Theage-adjusted prevalence for HSV-2 was 17.3% (95% CI, 15.2–19.4).Prevalence ranged from 7.1% (ages, 15–19 years) to 28.1% (ages,40–44 years), with the largest increases after the age of 24years.

Conclusions: TheHSV-2 seroprevalence among pregnant women in British Columbia is similar tothat in the United States and other countries. Seroprevalence continues torise through the later reproductive years. This observation may relate tocontinued transmission, an age cohort effect, orboth.

© Copyright 2001 American Sexually Transmitted Diseases Association

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