Study Design: This retrospective study reviewed five patients with scoliosis associated with cerebral gigantism (Sotos syndrome).
Objective: To clarify the clinical characteristics and progression of scoliosis in patients with cerebral gigantism.
Summary of Background Data: Little has been reported about spinal deformity in this syndrome.
Methods: The records and radiographs of five patients were reviewed.
Results: Scoliosis was first noticed at the age of 5 years in one case and at 6-16 months in the others. Their curve patterns were not consistent. Cobb's angles increased rapidly by 4 years of age and after 8 years of age despite attempts at bracing.
Conclusions: Excessive growth in infancy and growth-spurt period after 8 years of age may be related to the rapid progression of scoliosis in the same period.