Skip Navigation LinksHome > July 15, 2014 - Volume 39 - Issue 16 > Dynamic Contrast–Enhanced Magnetic Resonance Perfusion Compa...
Spine:
doi: 10.1097/BRS.0000000000000409
Diagnostics

Dynamic Contrast–Enhanced Magnetic Resonance Perfusion Compared With Digital Subtraction Angiography for the Evaluation of Extradural Spinal Metastases: A Pilot Study

Mazura, Jan C. MD*; Karimi, Sasan MD; Pauliah, Mohan PhD; Banihashemi, Mohammad Amin MD; Gobin, Y. Pierre MD; Bilsky, Mark H. MD§; Patsalides, Athos MD

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Abstract

Study Design. This was a retrospective study comparing dynamic contrast–enhanced magnetic resonance (DCE-MR) perfusion with digital subtraction angiography (DSA) in determining the vascularity of spinal tumors.

Objective. To report on the efficacy of DCE-MR perfusion as a potential noninvasive surrogate for measuring vascularity and thus determine the need for preoperative embolization.

Summary of Background Data. Although primary spinal tumors are rare, spine metastases are relatively common and symptomatic in approximately 14% of patients. Symptomatic patients require palliation with radiotherapy and/or surgery, with possible preoperative endovascular embolization of the tumor.

Methods. A retrospective review revealed 10 patients with 11 diseased vertebral bodies who had received spine DCE-MR perfusion studies and subsequently underwent spinal DSA. Processed MR data were used to calculate a blood flow ratio comparing blood flow with a diseased and an adjacent normal vertebral body. Spinal tumor vascularity was graded on the basis of angiographic tumor blush from 0 (decreased enhancement compared with a normal vertebral body) to 4 (marked tumor blush with early arteriovenous shunting).

Results. Eight vertebral bodies demonstrated increased vascularity on DSA with blood flow ratios of greater than 1.8, 2 vertebral bodies demonstrated normal enhancement on DSA with cerebral blood flow (CBF) ratio of 0.55 to 1.14, and 1 vertebral body level had decreased enhancement on DSA, with a CBF ratio of 0.43. There was a strong correlation between CBF ratio and DSA score, with Spearman ρ = 0.87 (P = 0.00012).

Conclusion. These data show a statistically significant correlation between CBF ratio and DSA and suggest that DCE-MR perfusion can serve as a surrogate to DSA for determining tumor vascularity in patients with extramedullary spinal metastases.

Level of Evidence: 3

© 2014 by Lippincott Williams & Wilkins

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