Skip Navigation LinksHome > December 01, 2013 - Volume 38 - Issue 25 > In Vivo Discography in Degenerate Porcine Spines Revealed Pr...
Spine:
doi: 10.1097/01.brs.0000435141.61593.05
Biomechanics

In Vivo Discography in Degenerate Porcine Spines Revealed Pressure Transfer to Adjacent Discs

Hebelka, Hanna MD*; Nilsson, Andreas MSc; Ekström, Lars BSc; Hansson, Tommy MD, PhD

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Abstract

Study Design. In vivo experimental porcine study.

Objective. To investigate if discography induced pressure increase in adjacent degenerate discs.

Summary of Background Data. Despite refinements in the past 2 decades, the validity of discography is debated. Discography in healthy pigs has shown that the pressure increase during disc injection transmits to adjacent discs, a potential source for false positive responses.

Methods. Degeneration in 1 lumbar disc was induced in 10 pigs by drilling a hole through the endplate. Intradiscal pressure was recorded using a 0.36-mm fiber-optic pressure transducer inserted into nucleus pulposus through a 22-gauge needle. The pressure was measured simultaneously in 2 adjacent discs during slow (0.03 mL/s) automated contrast injection into 1 of the discs up to 8 bar (116 psi). Ten adjacent discs were prefilled with contrast from previous discogram. A pressure increase 2 psi or more above baseline was defined as increased pressure in adjacent discs. Pressure was recorded until 15 minutes after injection.

Results. A total of 28 discograms were successfully performed. A pressure increase during injection was detected in 57% (16) of the 28 adjacent discs with mean 3.2 psi (1.7–8.2; standard deviation, 1.8), corresponding to a mean increase above baseline of 11%. Of those 16 adjacent discs, 4 were nondegenerate and 12 degenerate, of which 7 were prefilled. Fifteen minutes after injection, 89% of adjacent discs displayed increase in pressure of mean 14% above baseline.

Conclusion. Discography induced pressure increase in adjacent discs in a degenerate disc model, something not reported earlier. If present, also in human spine pressure transmission, may be a potential cause for false positive discography responses.

Level of Evidence: 3

© 2013 by Lippincott Williams & Wilkins

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