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Prediction of Massive Blood Loss in Scoliosis Surgery From Preoperative Variables

Yu, Xuerong MD; Xiao, Han MD; Wang, Ruiying MD; Huang, Yuguang MD

doi: 10.1097/BRS.0b013e31826c63cb

Study Design. A retrospective cohort study.

Objective. To identify predictors of massive blood loss after scoliosis surgery.

Summary of Background Data. Scoliosis surgery may be associated with considerable blood loss. Many blood conservation techniques have been used to reduce the allogeneic transfusion. An ability to identify patients with high risk of massive blood loss preoperatively may be helpful for appropriate use of these techniques.

Methods. Data of patients undergoing scoliosis surgery between June 1, 2011, and October 31, 2011, were collected. Preoperative information and total blood loss, which was calculated as the sum of intraoperative and postoperative estimated blood loss, were recorded. Patients were divided into 2 groups, retrospectively: group A (n = 95) with the total blood loss more than 30% of estimated blood volume and group B (n = 64) with the total blood loss of 30% of estimated blood volume or less. Preoperative data were compared between the groups. Significant variables were selected for a forward stepwise binary logistic regression analysis to determine the independent risk factors of massive blood loss.

Results. More than half of the patients (59.7%) undergoing scoliosis surgery had massive blood loss. Patients in group A were shorter (P = 0.01) and had larger preoperative Cobb angle (P < 0.01), more levels fused (P < 0.01), and more osteotomies (P < 0.01) than those in group B. Preoperative Cobb angle more than 50º (P = 0.017, odds ratio = 2.47, 95% confidence interval: 1.17–5.20), the number of fused levels more than 6 (P = 0.014, odds ratio = 3.70, 95% confidence interval: 1.31–10.49), and osteotomy (P = 0.000, odds ratio = 4.64, 95% confidence interval: 1.97–10.94) were determined to be the independent risk factors of massive blood loss in scoliosis surgery.

Conclusion. Risk of massive blood loss (total blood loss > 30% of estimated blood volume) in patients with scoliosis could increase, if they (1) had preoperative Cobb angle larger than 50º or (2) planned to undergo osteotomy or fusion of more than 6 levels.

This study showed that 59.7% of patients who underwent scoliosis surgery had massive blood loss (total blood loss > 30% of estimate blood volume), which could be predicted by the preoperative Cobb angle, the number of fused levels, and osteotomy.

From the Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.

Address correspondence and reprint requests to Yuguang Huang, MD, Department of Anesthesiology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, China; E-mail:

Acknowledgment date: March 1, 2012. First revision date: April 29, 2012. Second revision date: July 24, 2012. Acceptance date: July 28, 2012.

The manuscript submitted does not contain information about medical device(s)/drug(s).

No funds were received in support of this work.

No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

© 2013 Lippincott Williams & Wilkins, Inc.