Retrospective cohort study.
To determine the influence of age, comorbidities, and treatment type on mortality in elderly patients with acute Type II odontoid fractures.
Prior studies have documented increased morbidity and mortality among geriatric patients sustaining odontoid fractures. However, there is limited data regarding the effect of patient age, medical comorbidities, and treatment selection on mortality after Type II odontoid (C2) fractures in the elderly.
An institutional registry was used to identify all Type II odontoid fractures sustained by patients aged 65 and older from 1991 to 2006. Demographic information, date of injury, associated injuries, treatment type, and comorbidities were abstracted from medical records. Mortality was ascertained using the National Death Index. Risks of mortality and their associated 95% confidence intervals (CIs) were calculated at 3 months, 1 year, 2 years, and 3 years. Multivariable Cox proportional hazard regression was used to evaluate independent factors affecting mortality stratified by age (65–74 years, 75–84 years, ≥85 years) and treatment type (operative or nonoperative treatment, and halo or collar immobilization).
Of 156 patients identified with Type II odontoid fracture, the average age was 82 years (SD = 7.8; Range: 65–101). One hundred and twelve patients (72%) were treated nonoperatively. At 3 years postinjury, there was a 39% (95% CI: 32–47) mortality rate for the entire cohort. Mortality for the operative group was 11% (95% CI: 2–21) at 3 months and 21% (95% CI: 9–32) at 1 year compared with 25% (95% CI: 17–33) at 3 months and 36% (95% CI: 27–45) at 1 year in the nonoperative group. The Cox regression model showed that the protective effect of surgery was seen in patients aged 65 to 74 years, in whom the hazard ratio associated with surgery for mortality after odontoid fracture was 0.4 (95% CI: 0.1–1.5). Those aged 75 to 84 years had a hazard ratio of 0.8 (95% CI: 0.3–2.3), and patients 85 years or older had a hazard ratio of 1.9 (95% CI: 0.6–6.1; P value for interaction between age and treatment = 0.09) with operative treatment having a protective effect in patients aged 65 to 74 years.
In a cohort of elderly patients, Type II odontoid fractures were associated with a high rate of mortality, regardless of intervention.
A retrospective review of 156 elderly patients treated for Type II odontoid fractures showed a high rate of mortality, regardless of intervention. The data did not provide sufficient evidence that surgery offers a protective benefit for patients older than 75 years, although this observation may reflect selection bias.
*Department of Orthopaedic Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, MA
†Department of Orthopaedic Surgery, Harvard Medical School, Spine Service, Brigham and Women's Hospital, Boston, MA
‡Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA
§Spine Surgery Service, Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA
¶Department of Orthopaedic Surgery, Harvard Medical School, Spine Service, Massachusetts General Hospital, Boston, MA
∥Department of Orthopaedic Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, MA
**Departments of Orthopaedic Surgery and Rheumatology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA
††Department of Orthopaedic Surgery, Harvard Medical School, Orthopaedic Trauma Service, Brigham and Women's Hospital, Boston, MA
Address correspondence and reprint requests to Mitchel B. Harris, MD, FACS, Department of Orthopaedic Surgery, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; E-mail: firstname.lastname@example.org
Acknowledgment date: July 1, 2009. First revision date: December 3, 2009. Second revision date: February 18, 2010. Acceptance date: April 9, 2010.
The manuscript submitted does not contain information about medical device(s)/drug(s).
No funds were received in support of this work. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.