Skip Navigation LinksHome > December 15, 2008 - Volume 33 - Issue 26 > The Repercussions of Spinal Cord Injury on the Action of the...
doi: 10.1097/BRS.0b013e31818a2c59
Cervical Spine

The Repercussions of Spinal Cord Injury on the Action of the Diaphragmatic Crura for Gastroesophageal Reflux Containment

Silva, Cleuza B. MS*; Martinez, Júlio C. MD, PhD†; Yanagita, Edison T. MD†; Morais, José F. MS*; Carvalho, Luciane B. PhD‡; Herani-Filho, Benedito MD, PhD§; Moraes, Daniel G. MD¶; Vianna, Patrícia C. MD‖; Prado, Gilmar F. MD, PhD**

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Study Design. Cross-sectional and nonexperimental.

Objective. To detect and compare functional abnormalities in the esophagus and esophagogastric junction in 2 groups with chronic spinal injuries, 1 with injuries at the phrenic innervation level and the other at upper thoracic levels, and to relate these to gastroesophageal reflux containment.

Summary of Background Data. There are no studies on esophageal manometry with pH metering among spinal cord injury patients. Worldwide statistics reveal that the prevalence of gastroesophageal reflux disease among spinal cord injury patients is greater than among the general population, at around 22% to 27%. The “diaphragmatic crura” has been recognized as an important antireflux barrier and should functionally be considered to be a muscle separated from the costal diaphragm. However, doubts remain regarding whether this difference relates to its innervation.

Methods. This was a cross-sectional study on 29 patients with complete spinal cord injuries: 14 quadriplegics (level C4) and 15 paraplegics (levels T1-T7). Functional abnormalities of the esophagogastric junction, esophagus, and diaphragm were investigated using esophageal manometry and diaphragmatic video fluoroscopy. Presence of gastroesophageal reflux was investigated subjectively (pyrosis and regurgitation) and objectively (pH metering and endoscopy).

Results. The incidence of gastroesophageal reflux disease was 27.6%, without difference between the groups. This became statistically significant when the mean diaphragmatic crural pressures were compared (quadriplegics: 37.5 ± 17.8; paraplegics: 26.6 ± 7.2; P = 0.048). It was also significant in relation to the prevalence of at least one of the objective and/or subjective reflux findings and/or esophageal peristaltism (quadriplegics: 85.7%; paraplegics: 40.0%; P = 0.011).

Conclusion. Spinal injury at the level of the phrenic innervation did not predispose the quadriplegics toward greater risk of developing gastroesophageal reflux disease. Paradoxically, manometry showed significantly greater crural contractility among the quadriplegics.

© 2008 Lippincott Williams & Wilkins, Inc.

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