Study Design. Literature review, expert panel, and a workshop during the “VIII International Forum on Primary Care Research on Low Back Pain” (Amsterdam, June 2006).
Objective. To develop practical guidance regarding the minimal important change (MIC) on frequently used measures of pain and functional status for low back pain.
Summary of Background Data. Empirical studies have tried to determine meaningful changes for back pain, using different methodologies. This has led to confusion about what change is clinically important for commonly used back pain outcome measures.
Methods. This study covered the Visual Analogue Scale (0–100) and the Numerical Rating Scale (0–10) for pain and for function, the Roland Disability Questionnaire (0–24), the Oswestry Disability Index (0–100), and the Quebec Back Pain Disability Questionnaire (0–100). The literature was reviewed for empirical evidence. Additionally, experts and participants of the VIII International Forum on Primary Care Research on Low Back Pain were consulted to develop international consensus on clinical interpretation.
Results. There was wide variation in study design and the methods used to estimate MICs, and in values found for MIC, where MIC is the improvement in clinical status of an individual patient. However, after discussion among experts and workshop participants a reasonable consensus was achieved. Proposed MIC values are: 15 for the Visual Analogue Scale, 2 for the Numerical Rating Scale, 5 for the Roland Disability Questionnaire, 10 for the Oswestry Disability Index, and 20 for the QBDQ. When the baseline score is taken into account, a 30% improvement was considered a useful threshold for identifying clinically meaningful improvement on each of these measures.
Conclusion. For a range of commonly used back pain outcome measures, a 30% change from baseline may be considered clinically meaningful improvement when comparing before and after measures for individual patients. It is hoped that these proposals facilitate the use of these measures in clinical practice and the comparability of future studies. The proposed MIC values are not the final answer but offer a common starting point for future research.
There is a confusion about what change is clinically important for commonly used back pain outcome measures. This article provides practical guidance regarding the minimal important change (MIC) for commonly used outcome measures for pain and functional status, hopefully facilitating the use of these measures in clinical practice and the comparability of future studies.
From the *EMGO Institute, VU University Medical Centre; †Institute for Health Sciences, VU University, Amsterdam, The Netherlands; ‡Department of Medicine, University of Washington, Seattle, WA; §Department of Clinical Epidemiology and Biostatistics, School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada; ¶UnumProvident Centre for Psychosocial and Disability Research, Cardiff University, Cardiff, UK; ∥Primary Care Musculoskeletal Research Centre, Keele University, UK; **Centre for Health Studies, Group Health Cooperative, Seattle, WA; and ††Executive Board of VU University, Amsterdam, The Netherlands.
Acknowledgment date: April 4, 2007. Revision date: April 26, 2007. Acceptance date: May 10, 2007.
The manuscript submitted does not contain information about medical device(s)/drug(s).
No funds were received in support of this work. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.
Address correspondence and reprint requests to Raymond W.J.G. Ostelo, PhD, EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands; E-mail: email@example.com, www.emgo.nl