Genetics of Familial Idiopathic ScoliosisHadley Miller, Nancy MDSpine: 15 September 2000 - Volume 25 - Issue 18 - pp 2416-2418 Spine Update Abstract Author Information The etiology of familial idiopathic scoliosis remains in question. The role of genetic factors in the development of this disorder has been well-documented; however, reports of the specific mode of genetic inheritance are inconclusive. These facts, combined with the phenotypic variability of this disorder, suggest that the genetic expression if idiopathic scoliosis may be dependent upon multiple factors and genetic interactions. Strategies to resolve the complex nature of this condition include genome-wide scanning of one extensive family or, alternatively, a well-characterized population of families affected with idiopathic scoliosis. From the Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, Maryland. Acceptance date: May 15, 2000. Address reprint requests to Nancy Hadley Miller, MD Department of Orthopaedic Surgery Johns Hopkins University 601 North Caroline Street, #5254 Baltimore, MD 21287-0882 © 2000 Lippincott Williams & Wilkins, Inc.