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Genetics of Familial Idiopathic Scoliosis

Hadley Miller, Nancy MD

Spine:
Spine Update
Abstract

The etiology of familial idiopathic scoliosis remains in question. The role of genetic factors in the development of this disorder has been well-documented; however, reports of the specific mode of genetic inheritance are inconclusive. These facts, combined with the phenotypic variability of this disorder, suggest that the genetic expression if idiopathic scoliosis may be dependent upon multiple factors and genetic interactions. Strategies to resolve the complex nature of this condition include genome-wide scanning of one extensive family or, alternatively, a well-characterized population of families affected with idiopathic scoliosis.

Author Information

From the Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, Maryland.

Acceptance date: May 15, 2000.

Address reprint requests to

Nancy Hadley Miller, MD

Department of Orthopaedic Surgery

Johns Hopkins University

601 North Caroline Street, #5254

Baltimore, MD 21287-0882

© 2000 Lippincott Williams & Wilkins, Inc.