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Skip Navigation LinksHome > May 2008 - Volume 101 - Issue 5 > Necrotizing Panniculitis: A Skin Condition Associated with A...
Southern Medical Journal:
doi: 10.1097/SMJ.0b013e31816bf5eb
Case Report

Necrotizing Panniculitis: A Skin Condition Associated with Acinar Cell Carcinoma of the Pancreas

Lakhani, Aly MBBS; Maas, Luis MD, FACP, FACG, AGAF

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Abstract

Pancreatic panniculitis (PP) is a rare cutaneous eruption that is associated with severe pancreatic disease. A patient presented with a fever, joint pains, and an erythematous rash with draining pustules that had spread from his legs to his arms over 4 months. Thorough investigation revealed stage IV acinar cell carcinoma of the pancreas. The rash was a result of necrotizing PP. The variable cutaneous manifestations of internal malignancies may challenge primary care physicians and dermatologists when patients present without findings associated with malignancy. Panniculitis should be kept in mind in the differential diagnosis of inflamed appearing nodules and pustules with an erythematous base, particularly when they are progressive and unrelenting.

Key Points

* The skin manifestations of internal malignancies vary in their presentation.

* Primary care physicians and dermatologists may be challenged when patients present without other associated distinct findings for malignancy.

* Panniculitis or nodular subcutaneous fat necrosis should be kept in mind in the differential diagnosis of inflamed appearing nodules and pustules with an erythematous base, particularly when they are progressive and unrelenting. They may be the clue to the discovery of a potentially serious disease.

© 2008 Southern Medical Association

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