Infection in the setting of shoulder arthroplasty is a devastating complication. Eradication of the infection is paramount to clinical success in most patients. This often involves removal of the primary arthroplasty and placement of an antibiotic-impregnated cement spacer for a period of time. Once infection has cleared, reimplantation may be attempted. We describe in detail our technique of prosthesis with antibiotic-loaded acrylic cement formation and implantation for the proximal humerus. Clinical results are summarized.