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doi: 10.1097/SHK.0b013e3182597cab
Program

Seventh Congress of the International Federation of Shock Societies Thirty-Fifth Annual Conference on Shock: Eden Roc Renaissance Resort & Spa Miami Beach, Florida June 9 – 13, 2012

Free Access

Saturday, June 9, 2012

8:00 AM – 11:00 AM US Shock Council Meeting

Lapidus/Watson Timothy Buchman, PhD, MD, President Emory University School of Medicine, Atlanta, GA

11:00 – 12:30 PM IFSS Council Meeting

Key Biscayne Irshad Chaudry, PhD, President University of Alabama at Birmingham, Birmingham, AL

12:00 – 6:00 PM Registration

Key Biscayne Irshad Chaudry, PhD, President University of Alabama at Birmingham, Birmingham, AL

12:00 – 6:00 PM Registration

Ocean Tower I Foyer

1:30 – 2:00 PM Welcome

Ocean Tower II Irshad Chaudry, PhD, President, International Federation of Shock Societies Timothy Buchman, PhD, MD, President, US Shock Society

Introductions Presidents of International Shock Societies and US Shock Society

2:00 – 5:30 PM Plenary Symposium I

Ocean Tower II Shock Research From Around the Globe Irshad Chaudry, PhD, President, International Federation of Shock Societies University of Alabama at Birmingham, Birmingham, AL Ansgar Aasen, MD, PhD Oslo University Hospital, Oslo, Norway

2:00 – 2:25 PM Four Vertices of Shock Research in the USA; Mechanism, Measurement, Mitigation, and Money

Timothy Buchman, PhD, MD, President, US Shock Society Emory University School of Medicine, Atlanta, GA

2:25 – 2:50 PM Microparticles as Important Contributors to Sepsis Pathophysiology

Luciano Azevedo, MD, PhD, President, Brazilian Shock Society University of São Paulo School of Medicine, São Paulo, Brazil

2:50 – 3:15 PM DAMPS: A New Way to Understand Inflammatory Responses

Yong Jiang, MD, PhD, President, China Shock Society Southern Medical University, Guangzhou, Guangdong, China

3:15 – 3:30 PM Refreshment Break

3:30 – 3:55 PM 21 Years of European Shock Research, from Vienna to Miami

Soheyl Bahrami, PhD, President, European Shock Society Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

3:55 – 4:20 PM Antibiotic Prescription Behavior in Managing Sepsis

Amin Soebandrio, MD, PhD, President, Indonesian Shock Society Minister’s Adviser for Health and Medicine, Ministry for Research and Technology, Jakarta, Indonesia

4:20 – 4:45 PM The Perspective of Shock Research in Japan

Masao Miyashita, MD, PhD, President, Japan Shock Society Nippon Medical School, Tokyo, Japan

6:00 – 7:00 PM Presidential Address: US Shock Society

Ocean Tower II Lost in Translation? The Obligation of Research Continuum

Basilia Zingarelli, MD, PhD Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

7:00 – 8:00 PM Presidential Reception: Shock Society and International Federation of Shock Societies

Ocean Garden

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DINNER – ON YOUR OWN

Sunday, June 10, 2012

7:00 – 9:00 AM Poster Session 1 (Abstracts P1 – P57)

Pompei/Promenade Continental Breakfast

7:00 – 9:00 AM Editorial Board Breakfast (Invitation only)

Lapidus /Watson

9:00 – 11:30 AM Plenary Symposium II

Ocean Tower II The Influence of Predisposing Conditions on the Pathophysiology of Injury and Sepsis

Mashkoor Choudhry, PhD Loyola University Medical Center, Maywood, IL Ori Rotstein, MD St. Michael’s Hospital, Toronto, Canada

9:00 – 9:20 AM Calcium Channels, ROS Signaling and Response to Sepsis

Asrar Malik, PhD University of Illinois at Chicago, College of Medicine, Chicago, IL

9:20 – 9:40 AM Alcohol Abuse and the Injured Host Dysregulation of Neuroendocrine Mechanism

Patricia Molina, MD, PhD Louisiana State University Health Sciences Center, New Orleans, LA

9:40 – 10:00 AM Aging Exacerbates Inflammatory Responses After Injury

Elizabeth Kovacs, PhD Loyola University, Maywood, IL

10:00 – 10:20 AM The Two Hit Response as a Predisposing Factor to Trauma and Sepsis Complications

Ori Rotstein, MD St. Michael’s Hospital, Toronto, Canada

10:20 – 10:33 AM Pre-Existing Immune Phenotype Impacts the Host Response and Survival During Sepsis (Abstract 1)

David Hildeman, PhD Cincinnati Children’s Hospital, Cincinnati, OH

10:33 – 10:46 AM Impaired Innate and Adaptive Immunity of Accelerated-Aging Klotho Mice with Sepsis (Abstract 2)

Shigeaki Inoue, MD, PhD Tokai University, Kanagawa, Japan

10:46 – 10:59 AM A Novel Role for Tumor-Induced Expansion of Myeloid Derived Cells in Host Resistance and Cancer Cachexia (Abstract 3)

Alex Cuenca, MD University of Florida, Gainesville, FL

10:59 – 11:12 AM Circadian Rhythms Influence Sepsis Severity Depending on the Timing of CLP Surgery (Abstract 4)

Wendy Walker, PhD Yale School of Medicine, New Haven, CT

11:30 – 12:30 PM Boxed Lunch

12:30 – 3:00 PM New Investigator Competition

Ocean Tower II

12:30 – 12:45 PM Early Stabilizing Alveolar Ventilation Prevents ARDS (Abstract 5)

Shreyas Roy, MD SUNY Upstate Medical University, Syracuse, NY

12:45 – 1:00 PM WNT Agonist Attenuates Liver Injury and Improves Survival After Hepatic Ischemia/Reperfusion (Abstract 6)

Michael Kuncewitch, MD The Feinstein Institute for Medical Research, Manhasset, NY

1:00 – 1:15 PM Parasympathetic Stimulation Prevents Systemic Organ Dysfunction by Abrogating Gut Injury and Lymph Toxicity in Trauma and Hemorrhagic Shock (Abstract 7)

Gal Levy, MD UMDNJ-New Jersey Medical School, Newark, NJ

1:15 – 1:30 PM IL-22 Modulates Gut Epithelial and Immune Barrier Functions Following Acute Alcohol Intoxication and Burn Injury (Abstract 8)

Juan Rendon, BSN Loyola University, Maywood, IL

1:30 – 1:45 PM Silencing of FAS, FADD or CASPASE-3 (C-3) Differentially Affects Lung Inflammation, Apoptosis and Development of Septic Acute Lung Injury (ALI) (Abstract 9)

Mirko Messer, PhD Ulm University, Ulm, Germany

1:45 – 2:00 PM The Impact of Cardiac Arrest Duration on Extravascular Lung Water and Pulmonary Vascular Permeability in Post-Cardiac Arrest Patients (Abstract 10)

Takashi Tagami, MD Department of Emergency and Critical Care Medicine, Aidu Chuo Hospital, Fukushima, Japan

2:00 – 2:15 PM Fibrinogen Gamma-Chain Peptide-Coated, Adenosine Diphosphate-Encapsulated Liposomes Rescue Thrombocytopenic Rabbits from Non-Compressible Liver Hemorrhage (Abstract 11)

Kahoko Nishikawa, MD National Defense Medical College, Saitama, Japan

2:15 – 2:30 PM ROS Formation Under Restrictive Versus Full Reperfusion Following Hemorrhagic Traumatic Shock

Carina Penzenstadler, DVM Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

2:30 – 2:45 PM Cracking Septic Brains: Regional (Dys)functions Separate Survivors from Non-Survivors

Katrin Weixelbaumer, DVM Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

3:00 – 3:15 PM Refreshment Break

3:15 – 6:00 PM Parallel Symposium I

Ocean Tower II Traumatic Brain Injury: Prevalence, Diagnosis and Treatment

Irshad Chaudry, PhD University of Alabama at Birmingham, Birmingham, AL Ingo Marzi, MD J. W. Goethe University Hospital, Frankfurt, Germany

3:15 – 3:35 PM Occurrence and Prevalence of Traumatic Brain Injury in Civilian and Military Population

Peter M. Rhee, MD University of Arizona, Tucson, AZ

3:35 – 3:55 PM Suitable Models, Pathophysiological Sequelae, and Biomarkers in TBI

Ingo Marzi, MD J. W. Goethe University Hospital, Frankfurt, Germany

3:55 – 4:15 PM Diagnosis of Traumatic Brain Injury and Novel Treatment Modalities for TBI

Deborah Stein, MD, MPH University of Maryland School of Medicine, Baltimore, MD

4:15 – 4:35 PM Progesterone in the Treatment of Brain Injury: Basic and Clinical Findings

Donald Stein, PhD Emory University School of Medicine, Atlanta, GA

4:35 – 4:55 PM Estrogen for the Treatment of TBI

Irshad Chaudry, PhD University of Alabama at Birmingham, Birmingham, AL

4:55 – 5:08 PM Increased Functional Activity of Endogenous Acetylcholine on Brain M1 Muscarinic Receptors Suppresses Lethal Peripheral Inflammation (Abstract 12)

Valentin Pavlov, PhD The Feinstein Institute for Medical Research, Manhasset, NY

5:08 – 5:21 PM The Immune Response to Bacterial Pneumonia Following Traumatic Brain Injury is Enhanced in the Periphery but Decreased in the Lung (Abstract 13)

David Stepien, MS Boston University School of Medicine, Boston, MA

5:21 – 5:34 PM Indirect Brain Injury Resulting from Severe Burns Results in Estrogen Reversible Elevations of Markers of Alzheimer’s Disease (AD) Over the First 45 Days Post-Burn (Abstract 14)

Jane Wigginton, MD University of Texas Southwestern Medical Center, Dallas, TX

5:34 – 5:47 PM S100B and NSE as Predictive Biomarkers of Outcome in Resuscitated TBI Patients (Abstract 15)

Andrew Baker, MD St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada

5:47 – 6:00 PM Genetic Deletion of Toll-Like Receptor 4 Reveals Their Role in Neurovascular Unit and Secondary Inflammatory Process After Traumatic Brain Injury in Mice (Abstract 16)

Akbar Ahmad, PhD Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, Messina, Italy

3:15 – 6:00 PM Parallel Symposium 2

Ocean Tower I Pathways to Discovery: Cellular and Molecular Mediators of Injury and Shock

Michael Yaffe, PhD, MD Massachusetts Institute of Technology, Boston, MA Edmund Neugebauer, PhD University of Witten/Herdecke, Cologne, Germany

3:15 – 3:35 PM Molecular Dissection of the Signaling Pathways that Mediate Injury, Shock, and Sepsis

Michael Yaffe, PhD, MD Massachusetts Institute of Technology, Boston, MA

3:35 – 3:55 PM Modeling Trauma-Induced Coagulopathy

Mitchell Cohen, MD University of California - San Francisco, San Francisco, CA

3:55 – 4:15 PM Microparticles in Trauma-Hemorrhage

Marc Maegele, MD, PhD University of Witten/Herdecke, Cologne, Germany

4:15 – 4:35 PM Innovative Animal Models for Injury, Shock, and Sepsis Research

Philip Efron, MD University of Florida, Gainesville, FL

4:35 – 4:48 PM Neutrophil-Derived Microparticles Contribute to Immune Paralysis During Sepsis (Abstract 17)

Priya Prakash, MD University of Cincinnati, Cincinnati, OH

4:48 – 5:01 PM Overexpression of Cardiac MicroRNA-146a Attenuates Myocardial Dysfunction in Polymicrobial Sepsis (Abstract 18)

Xiaohui Wang, MS East Tennessee State University, Johnson City, TN

5:01 – 5:14 PM A Small Molecule Sirtuin1 Activator Reduces Cytokine Release and Coagulation Activation in Human Endotoxemia (Abstract 19)

Anne van der Meer, MD Amsterdam Medical Center, Amsterdam, The Netherlands

5:14 – 5:27 PM Complement Factor B Expression is Regulated by Toll-Like Receptors and Plays an Important Role in Experimental Polymicrobial Sepsis (Abstract 20)

Lin Zou, MD, PhD Massachusetts General Hospital, Boston, MA

5:27 – 5:40 PM Estrogen Protects Against Oxidant-Induced Endothelial Damage by Restoring the Cortical Actin Cytoskeleton Through a Non-Genomic PIP2-Dependent Pathway (Abstract 21)

Helen L. Yin, PhD University of Texas Southwestern Medical Center, Dallas, TX

5:40 – 5:53 PM Opposite Roles of ASC and NLRP3 Inflammasomes in Host Defense During Infection with Serotype and 3 Streptococcus Pneumoniae (Abstract 22)

Miriam van Lieshout, MD Academic Medical Center, Amsterdam, The Netherlands

7:00 – 7:30 PM Reception

Ocean Tower I Foyer

7:30 – 9:30 PM Dinner

Ocean Tower I New Investigator Competition and Travel Awards Ceremony

Monday, June 11, 2012

6:00 – 7:00 AM 29th Annual Presidential Fun Run

Organized by Mark Clemens, PhD University of North Carolina, Charlotte, NC

7:00 – 9:00 AM Poster Session 2 (Abstracts P58 – P145)

Pompei/Promenade Continental Breakfast

9:00 – 10:00 AM Keynote Address: Alarmins can be Alarming!

Joost Oppenheim, MD National Cancer Institute, Frederick, MD

10:00 – 11:46 AM Plenary Symposium III

Ocean Tower II An International Perspective on New Treatments for Injury, Sepsis, and Organ Dysfunction

Hiroyuki Hirasawa, MD, PhD Chiba University Graduate School of Medicine, Chiba, Japan Richard Hotchkiss, MD Washington University School of Medicine, St. Louis, MO

10:00 – 10:20 AM Role of PPAR-Beta/Delta in Sepsis

Christoph Thiemermann, MD, PhD Queen Mary University of London, London, UK

10:20 – 10:40 AM Continuous Hemodiafiltration with Cytokine-Adsorbing Hemofilter in the Treatment of Severe Sepsis and Septic Shock

Hiroyuki Hirasawa, MD, PhD Chiba University Graduate School of Medicine, Chiba, Japan

10:40 – 11:00 AM Treating Sepsis with Cytokine Therapy

Richard Hotchkiss, MD Washington University School of Medicine, St. Louis, MO

11:00 – 11:20 AM Modulating T Cell Inhibitory Signal Transduction Components to Improve Immune Function

Carol Miller-Graziano, PhD University of Rochester Medical Center, Rochester, NY

11:20 – 11:33 AM Post-Burn, Single-Dose Estrogen Decreases Inflammation in the Heart for 45 Days Following Severe Burn Injury (Abstract 23)

Victoria Warren, RN University of Texas Southwestern Medical Center, Dallas, TX

11:33 – 11:46 AM β-ARRESTIN1: An Important Regulator of Inflammation and Bacterial Clearance in Polymicrobial Sepsis (Abstract 24)

Deepika Sharma, BE Michigan State University, East Lansing, MI

12:00 – 1:00 PM Shock Society Business Meeting

Ocean Tower II Timothy Buchman, PhD, MD

Emory University School of Medicine, Atlanta, GA

Free Afternoon – Lunch & Dinner on your own

Tuesday, June 12, 2012

7:00 – 9:00 AM Poster Session 3 (Abstracts P146 – P225)

Pompei/Promenade Continental Breakfast

9:00 – 12:00 Noon Plenary Symposium IV

Ocean Tower II Nutritional Influences on Critical Injuries

Paul Wischmeyer, MD

Alessandro Pontes-Arruda, MD, PhD

Fernandes Távora Hospital, Fortaleza, Ceará, Brazil

9:00 – 9:20 AM The Shockingly D-Lightful Health Benefits of Vitamin D

Michael Holick, PhD, MD

Boston University School of Medicine, Boston, MA

9:20 – 9:40 AM The Use of Fish Oil in the Treatment of Severe Sepsis and Septic Shock

Alessandro Pontes-Arruda, MD, PhD

Fernandes Távora Hospital, Fortaleza, Ceará, Brazil

9:40 – 10:00 AM Pre-Operative Nutrition in Surgery - Is it an Emergency in your Patients?

Paul Wischmeyer, MD

University of Colorado, Denver, CO

10:00 – 10:20 AM Glutamine-Changing Outcomes in the ICU- But Why?

Rosemary Kozar, MD, PhD

The University of Texas Medical School at Houston, Houston, TX

10:20 – 10:33 AM SYNDECAN-1 Mediates Gut Protection by Enteral Glutamine in a Rodent Model of Gut Ischemia/Reperfusion (Abstract 25)

Kechen Ban, PhD

University of Texas Health Science Center at Houston, Houston, TX

10:33 – 10:46 AM Hypertonic Saline Resuscitation Without Dextran Inhibits Neutrophil Activation (Abstract 26)

Wolfgang Junger, PhD

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

10:46 – 10:59 AM Altered Gut Flora in Patients with Sepsis: Survivors VS. Non-Survivors (Abstract 27)

Tomoki Yamada, MD

Osaka University Graduate School, Osaka, Japan

10:59 – 11:12 AM Immune-Enhancing Properties of Statin and Coenzyme Q10 Treatment in Sepsis (Abstract 28)

Akinori Osuka, MD

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

11:12 – 11:25 AM The Effect on Glycemic Control of a Low-Carbohydrate, High-Fat Enteral Formula in Critically Ill Patients Admitted to a Trauma and Critical Care Center (Abstract 29)

Naoki Nakamoto, MD

Osaka General Medical Center, Osaka, Japan

11:25 – 11:38 AM Protective Role of the Gut Microbiome in the Host Defense Against Streptococcus Pneumoniae Induced Pneumonia (Abstract 30)

Tim Schuijt, PhD

Academic Medical Center, Amsterdam, The Netherlands

12:30 – 1:30 PM Lunch

12:30 – 1:30 PM Oral Presentations by and for New Investigators

Ocean Tower I Brenda Smith, PhD

Oklahoma State University, Stillwater, OK

Yoram Vodovotz, PhD

University of Pittsburgh, Pittsburgh, PA

1:30 – 3:00 PM Parallel Symposium 3

Ocean Tower II The Significance of Stem Cells to Injury Research and Therapy

Celeste Finnerty, PhD

The University of Texas Medical Branch at Galveston, Galveston, TX

Heinz Redl, PhD

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

1:30 – 1:50 PM Overview on Stem Cell Use and Research for Trauma

Heinz Redl, PhD

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

1:50 – 2:10 PM Stem Cells as Treatments for Controlling the Sepsis Response

Krisztian Nemeth, MD, PhD

National Institutes of Health, Bethesda, MD

2:10 – 2:30 PM Therapeutic Potential of Mesenchymal Stem Cells for Acute Lung Injury

Jae Woo Lee, MD

University of California - San Francisco, San Francisco, CA

2:30 – 2:50 PM Mesenchymal Stem Cells Modulate Systemic Vascular Stability in Traumatic Injury

Shibani Pati, MD, PhD

University of California - San Francisco, San Francisco, CA

2:50 – 3:03 PM Beneficial Effect of a Stromal Cell-Derived Factor (SDF)-1! Analogue in CLP-Induced Sepsis (Abstract 31)

Hongkuan Fan, PhD

Medical University of South Carolina, Charleston, SC

3:03 – 3:16 PM The Protective Effect of Epidermal Growth Factor During Sepsis Depends on the Adaptive Immune System (Abstract 32)

Layla Jaffree, MD

Emory University School of Medicine, Atlanta, GA

1:30 – 3:00 PM Parallel Symposium 4

Ocean Tower I Resolution of the Injury Response

Laurie Kilpatrick, PhD

Temple University School of Medicine, Philadelphia, PA

Jean-Marc Cavaillon, PhD

Pasteur Institute, Paris, France

1:30 – 1:50 PM Anti-inflammatory Mechanisms in Severe Inflammation, Sepsis and Infection

Tom van der Poll, MD

Academic Medical Center, Amsterdam, The Netherlands

1:50 – 2:10 PM Nuclear Hormone Receptors and Organ Metabolic Recovery

Basilia Zingarelli, MD, PhD

Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

2:10 – 2:30 PM Leukocyte Reprogramming to Dampen Inflammatory Process

Jean-Marc Cavaillon, PhD

Pasteur Institute, Paris, France

2:30 – 2:50 PM Protein Kinase C and the Control of Inflammation

Laurie Kilpatrick, PhD

Temple University School of Medicine, Philadelphia, PA

2:50 – 3:03 PM Discovery of a Novel Small Molecule Inhibitor of Toll-Like Receptor 4 (TLR4) with Anti-Inflammatory Effects in Murine and Human Tissue (Abstract 33)

Matthew Neal, MD

University of Pittsburgh School of Medicine, Pittsburgh, PA

3:03 – 3:16 PM Inhibition of Lipogenesis Reduces Inflammation and Organ Injury Induced by Sepsis (Abstract 34)

Juan Idrovo, MD

Hofstra North Shore-LIJ School of Medicine, Manhasset, NY

3:15 – 6:00 PM Parallel Symposium 5

Ocean Tower II Alternative Medicine Approaches to Study and Treat Injury, Shock, and Sepsis

Charles Caldwell, PhD

University of Cincinnati College of Medicine, Cincinnati, OH

Manfred Thiel, MD

Ludwig Maximilians-University, Munich, Germany

3:15 – 3:35 PM Coronary Artery Disease, Endocannabinoids and the Inflammatory Response to Cardiac Surgery

Gustav Schelling, MD, PhD

Ludwig-Maximilians University, Munich, Germany

3:35 – 3:55 PM Methylxanthines in Inflammation and Sepsis

George Hasko, MD, PhD

University of Medicine and Dentistry of New Jersey, Newark, NJ

3:55 – 4:15 PM Endocannabinoid System in Inflammation and Sepsis

Christian Lehmann, MD, PhD

Dalhousie University Halifax, Nova Scotia, Canada

4:15 – 4:35 PM Therapeutic Potential of Herbal Components (Tanshinone and Carbenoxolone) in Sepsis

Haichao Wang, PhD

The Feinstein Institute for Medical Research, Manhasset, NY

4:35 – 4:55 PM Resveratrol Improves Cardiac Function Following Hemorrhagic Injury

Raghavan Raju, PhD

University of Alabama at Birmingham, Birmingham, AL

4:55 – 5:08 PM Resveratrol Improves Cognitive Performance in Concussed Athletes (Abstract 35)

Joshua Gaston, PhD

University of Texas Southwestern Medical Center, Dallas TX

5:08 – 5:21 PM Cannabinoid 2 Receptor Activation is Beneficial During a Murine Model of Sepsis (Abstract 36)

Charles Caldwell, PhD

University of Cincinnati College of Medicine, Cincinnati, OH

5:21 – 5:34 PM A Cardiovascular Herbal Medicine (Tanshinone IIA) Facilitates Cellular HMGB1 Uptake (Abstract 37)

Yusong Zhang, MD

The Feinstein Institute for Medical Research, Manhasset, NY

5:34 – 5:47 PM Mung Bean (Vigna Radiata) Extract is Protective Against Lethal Sepsis in Mice (Abstract 38)

Shu Zhu, MD, PhD

The Feinstein Institute for Medical Research, Manhasset, NY

5:47 – 6:00 PM Resveratrol Reduces Endoplasmic Reticulum Stress Following Trauma-Hemorrhage (Abstract 39)

Bixi Jian, MD

University of Alabama at Birmingham, Birmingham, AL

3:15 – 6:00 PM Parallel Symposium 6

Ocean Tower I Cellular and Molecular Responses to Hemorrhagic Shock

Joe Messina, PhD

University of Alabama at Birmingham, Birmingham, AL

Haim Bitterman, MD

Carmel Medical Center, Haifa, Israel

3:15 – 3:35 PM The Role of Non-Bacterial Gut Luminal Factors in the Pathogenesis of Trauma-Hemorrhagic Shock-Induced Gut Injury and Gut-Origin MODS

Edwin A. Deitch, MD

UMDNJ, New Jersey Medical School, Newark, NJ

3:35 – 3:55 PM Precipitating Lung Injury from the Combined Insults of Hemorrhagic Shock/Sepsis: From Cell Death to Programmed Cell Death Receptor-1

Alfred Ayala, PhD

Rhode Island Hospital/Brown University, Providence, RI

3:55 – 4:15 PM Oxygen Debt - An Ultimate Indicator of Severity in Hemorrhagic Shock?

Haim Bitterman, MD

Carmel Medical Center, Haifa, Israel

4:15 – 4:35 PM Multiple Mechanisms Leading to Acute Metabolic Dysregulation Following Hemorrhage

Joe Messina, PhD

University of Alabama at Birmingham, Birmingham, AL

4:35 – 4:48 PM Water Soluble Estrogens Prolong Permissive Hypotension Following Major Blood Loss Even Without Fluid Resuscitation (Abstract 40)

William Hubbard, PhD

University of Alabama at Birmingham, Birmingham, AL

4:48 – 5:01 PM TLR4 Antagonism Restored Cardiac Function After Trauma-Hemorrhage (Abstract 41)

Xia Zhang, MD

East Tennessee State University, Johnson City, TN

5:01 – 5:14 PM Adiponectin (ADPN) is a Key Component in Fresh Frozen Plasma (FFP) Responsible for its Endothelial Protective Effects After Hemorrhagic Shock (HS) (Abstract 42)

Xiyun Deng, PhD

The University of Texas Health Science Center at Houston, Houston, TX

5:14 – 5:27 PM Serum Metabolomic Analysis of the Effects of Glucose Pre-Feed on Metabolism in a Porcine Model of Polytrauma and Hemorrhagic Shock (Abstract 43)

Daniel Lexcen, PhD

University of Minnesota, Minneapolis, MN

5:27 Y 5:40 PM Hyperoxemic Reoxygenation Does Not Increase ROS Formation During Reperfusion After Hemorrhagic Traumatic Shock Associated with Hypoxia (Abstract 44)

Carina Penzenstadler, DVM

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

5:40 – 5:53 PM Diluting the Survival Benefit of Hemostatic Resuscitation (Abstract 45)

Chrissy Guidry, DO

Tulane University, New Orleans, LA

7:00 – 7:30 PM Reception

Ocean Tower I Foyer

7:30 – 9:30 PM Dinner

Ocean Tower I Scientific Achievements and Service Awards Ceremony

Wednesday, June 13, 2012

7:00 – 9:00 AM Poster Session 4 (Abstracts P226 – P274)

Pompei/Promenade Continental Breakfast

9:00 – 12:00 PM Plenary Symposium V

Ocean Tower II Endogenous Triggers of the Injury Response

Carl Hauser, MD

Beth Israel Deaconess Medical Center, Boston, MA

Eugen Faist, MD

Ludwig Maximilians-University, Munich, Germany

9:00 – 9:20 AM Conversations Between Tissues and T Cells

Polly Matzinger, PhD

National Institutes of Health, Bethesda, MD

9:20 – 9:40 AM Cell-Specific TLR4 Response to Injury

Timothy Billiar, MD

University of Pittsburgh, Pittsburgh PA

9:40 – 10:00 AM Endogenous and Exogenous DNA Damage Molecules as Biomarkers for Sterile Inflammation Versus Sepsis

Carl Hauser, MD

Beth Israel Deaconess Medical Center, Boston, MA

10:00 – 10:20 AM Immunomonitoring of DAMPS and PAMPS in Critical Illness: Crucial Information for More Differentiated Understanding of Acute Inflammatory States

Eugen Faist, MD

Ludwig Maximilians-University, Munich, Germany

10:20 – 10:33 AM HMGB1 Cysteine 106 is Required for Binding to MD-2 in the TLR4/MD2 Complex to Elicit Inflammatory Responses (Abstract 46)

Huan Yang, PhD

The Feinstein Institute for Medical Research, Manhasset, NY

10:33 – 10:46 AM Histones Activate NLRP3 Inflammasome Through Toll-Like Receptor 9-Dependent Pathway in Sterile Inflammatory Liver Injury (Abstract 47)

Hai Huang, MD

University of Pittsburgh Medical Center, Pittsburgh, PA

10:46 – 10:59 AM PKR is Required for NLRP3 Inflammasome Activation and HMGB1 Release (Abstract 48)

Ben Lu, MD

The Feinstein Institute for Medical Research, Manhasset, NY

10:59 – 11:12 AM Loss of MYD88 or TRIF Does Not Impact Survival to Neonatal Polymicrobial Sepsis (Abstract 49)

Dallas Joiner, HS

University of Florida, Gainesville, FL

11:12 – 11:25 AM The Alarmin S100A8/A9 Amplifies Ventilator-Induced Lung Injury (Abstract 50)

Maria Kuipers, MD

11:25 – 11:38 AM Role of Cell-Free DNA in Sepsis Pathophysiology: Novel Studies in Murine Models of Sepsis (Abstract 51)

Safiah Mai, HBSc

McMaster University, Ontario, Canada

©2012The Shock Society

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