ABSTRACT: New definitions of sepsis and septic shock were published in early 2016, updating old definitions that have not been revisited since 2001. These new definitions should profoundly affect sepsis research. In addition, these papers present clinical criteria for identifying infected patients who are highly likely to have or to develop sepsis or septic shock. In contrast to previous approaches, these new clinical criteria are evidence based. In this review, two of the authors of the new definitions detail the content of the papers and explore the implications for shock and sepsis researchers.
*5E Surgical Intensive Care Unit, Emory Critical Care Center, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia
†Department of Pediatrics, Hofstra—Northwell School of Medicine, Steven and Alexandra Cohen Children's Medical Center, New Hyde Park, New York
‡Feinstein Institute for Medical Research, Elmezzi Graduate School of Molecular Medicine, Manhasset, New York
Address reprint requests to Clifford S. Deutschman, MD, Cohen's Childrens Hospital, New Hyde Park, NY 11040. E-mail: firstname.lastname@example.org
Received 24 August, 2016
Revised 12 September, 2016
Accepted 26 September, 2016
The authors report no conflicts of interest.