Skip Navigation LinksHome > July 2014 - Volume 42 - Issue 1 > Role of Alveolar Macrophages in the Inflammatory Response Af...
doi: 10.1097/SHK.0000000000000167
Review Article

Role of Alveolar Macrophages in the Inflammatory Response After Trauma

Niesler, Ulrike*; Palmer, Annette*; Radermacher, Peter; Huber-Lang, Markus S.*

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ABSTRACT: Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), can result from both direct and indirect pulmonary damage caused by trauma and shock. In the course of ALI/ARDS, mediators released from resident cells, such as alveolar macrophages, may act as chemoattractants for invading cells and stimulate local cells to build up a proinflammatory micromilieu. Depending on the trauma setting, the role of alveolar macrophages is differentially defined. This review focuses on alveolar macrophage function after blunt chest trauma, ischemia/reperfusion, hemorrhagic shock, and thermal burns.

© 2014 by the Shock Society

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