Skip Navigation LinksHome > June 2014 - Volume 41 - Issue 6 > Role of Neutrophil Extracellular Traps Following Injury
Shock:
doi: 10.1097/SHK.0000000000000146
Review Articles

Role of Neutrophil Extracellular Traps Following Injury

Liu, Fu-Chao*†; Chuang, Yueh-Hsun; Tsai, Yung-Fong*†; Yu, Huang-Ping*†

Editor's Choice
Collapse Box

Abstract

ABSTRACT: Neutrophil extracellular traps (NETs), which consist of neutrophil DNA and cytoplasmic proteins, have been shown to be involved in various infectious, inflammatory, and autoimmune diseases. Neutrophil extracellular traps are abundant at the site of infection and acute inflammation. Neutrophil extracellular trap formation can occur through various intracellular signaling pathways, including peptidylarginine deiminase 4, Raf-MEK-ERK, nitric oxide, Toll-like receptor 4, high mobility group box 1, pentraxin 3, and mammalian targets of rapamycin. A growing body of evidence indicates that NETs may play an important role in injury, and decreases in NETs could reduce tissue injury. Neutrophil extracellular traps are believed to modulate the inflammatory and immune responses of individuals after injury. In this review, the role of NETs in injury, including traumatic injury, ischemia-reperfusion–induced injury, and sepsis, as well as the potential markers and therapeutic targets of NET-related injury will be discussed.

© 2014 by the Shock Society

Follow Us

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.