Shock

Skip Navigation LinksHome > August 2013 - Volume 40 - Issue 2 > Monocyte Human Leukocyte Antigen–DR Expression—A Tool to Dis...
Shock:
doi: 10.1097/SHK.0b013e318299ebdd
Clinical Aspects

Monocyte Human Leukocyte Antigen–DR Expression—A Tool to Distinguish Intestinal Bacterial Infections From Inflammatory Bowel Disease?

Tillinger, Wolfgang*; Jilch, Ruth; Waldhoer, Thomas; Reinisch, Walter§; Junger, Wolfgang

Collapse Box

Abstract

ABSTRACT: Background: We sought to determine the quantitative expression of human leukocyte antigen–DR (HLA-DR) on monocytes in patients with acute intestinal bacterial infections and inflammatory bowel disease (IBD). Methods: The quantitative expression of HLA-DR on monocytes was determined by fluorescence-activated cell sorting analysis in patients with IBD, patients with acute intestinal bacterial infections (bact.), and healthy subjects (contr.). Results: The quantitative expression of HLA-DR in patients with bact. (n = 20; 90,000 molecules per monocyte; confidence interval [CI], 79,000–102,000) was significantly higher than that in patients with ulcerative colitis (n = 40, 30,000; CI, 30,000–38,000; P < 0.0001), Crohn disease (n = 80, 31,000; CI, 32,000–39,000; P < 0.0001), or in contr. (n = 28, 39,000; CI, 36,000–46,000; P < 0.0001). In patients with ulcerative colitis and Crohn disease, HLA-DR expression was significantly decreased, as compared with contr. (P < 0.05 and P < 0.01, respectively). With a cutoff point of 50,000, HLA-DR showed a sensitivity of 95% and a specificity of 92% in discriminating between bact. and active IBD. Conclusion: The quantitative measurement of HLA-DR expression could serve as a valuable tool to discriminate between bact. and active IBD.

© 2013 by the Shock Society

Follow Us

 


Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.