Salmonella enterica serovar Typhimurium is a serious contagious pathogen. It often enters into the gastrointestinal tract via a faecal–oral route and causes nontyphoid symptoms such as high fever and acute diarrhoea. In many developing countries, Salmonella Typhimurium has already become the leading cause of human food poisoning. The PhoP/PhoQ locus is an ancestral two-component regulatory system related to the pathogenicity of Salmonella Typhimurium. In this review, we clarify the functional roles as well as the complicated regulatory networks of the PhoP/PhoQ system.
aInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu City
bAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Ya’an
cKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, Chengdu City, Sichuan, P. R. China.
Correspondence to Anchun Cheng, Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, 46# Xinkang Road, Yucheng District, Yaan 625014, China. Tel: +86 835 2885774; fax: +86 835 2885774; e-mail: Chenganchun@vip.163.com
Received 1 August, 2012
Accepted 19 September, 2012