Salmonella enterica serovar Typhimurium is a serious contagious pathogen. It often enters into the gastrointestinal tract via a faecal-oral route and causes nontyphoid symptoms such as high fever and acute diarrhoea. In many developing countries, Salmonella Typhimurium has already become the leading cause of human food poisoning. The PhoP/PhoQ locus is an ancestral two-component regulatory system related to the pathogenicity of Salmonella Typhimurium. In this review, we clarify the functional roles as well as the complicated regulatory networks of the PhoP/PhoQ system.
(C) 2012 Lippincott Williams & Wilkins, Inc.