Current treatments for most solid tumors include surgery, chemotherapy, radiotherapy, and so on. However, these methods have their own limitations; besides, it has been proved that solid tumors always possess relatively anaerobic areas that are closely related to tumor resistance and poor prognosis. Seeking new alternative treatments is urgent; trials using anaerobic bacteria to target this troublesome region were initiated years ago. Nontoxigenic Clostridium novyi (C. novyi-NT) possesses the capacity to colonize specific tumor causing tumor necrosis, and, most significantly, can be exploited to treat solid tumors combined with several current cancer therapies successfully. Undoubtedly, the application of C. novyi-NT in solid tumor therapy has been demonstrated as a novel and promising therapy.