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Role of nontoxigenic Clostridium novyi in solid tumor therapy

Zhang, Shuoa; Chen, Yea; Wang, Jiea; Tang, Feiyua; Miao, Tianyub; Li, Mingyuanc

Reviews in Medical Microbiology: July 2014 - Volume 25 - Issue 3 - p 71–76
doi: 10.1097/MRM.0000000000000005
Reviews

Current treatments for most solid tumors include surgery, chemotherapy, radiotherapy, and so on. However, these methods have their own limitations; besides, it has been proved that solid tumors always possess relatively anaerobic areas that are closely related to tumor resistance and poor prognosis. Seeking new alternative treatments is urgent; trials using anaerobic bacteria to target this troublesome region were initiated years ago. Nontoxigenic Clostridium novyi (C. novyi-NT) possesses the capacity to colonize specific tumor causing tumor necrosis, and, most significantly, can be exploited to treat solid tumors combined with several current cancer therapies successfully. Undoubtedly, the application of C. novyi-NT in solid tumor therapy has been demonstrated as a novel and promising therapy.

aWest China School of Preclinical and Forensic Medicine

bWest China School of Medicine

cDepartment of Medical Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Correspondence to Professor Mingyuan Li, Department of Medical Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Number 17, Renmin Road South, Chengdu, Sichuan 610041, People's Republic of China. Tel: +86 28 85501267; e-mail: lmy3985@sina.com

Received 21 December, 2013

Accepted 23 February, 2014

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins