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Epidemiology of carbapenem-resistant and noncarbapenem-resistant enterobacteriaceae and issues related to susceptibility testing, treatment options, and clinical outcome

Gowda, Lakshmana K.; Marie, Mohammed Ali M.

Reviews in Medical Microbiology:
doi: 10.1097/MRM.0000000000000004
Reviews
Abstract

Carbapenems are broad-spectrum β-lactam antibiotics that act by inhibition of cell wall synthesis. Various families of carbapenemases comprising numerous members have been identified, which may be plasmid or chromosomally encoded. More than one mechanism of carbapenem resistance (carbapenem-resistant enterobacteriaceae, CRE) has been identified with sporadic reports of CRE infection across the world. Appearance of carbapenem resistance in enterobacteriaceae is worrying as infection with these organisms has high mortality rates with fewer treatment options, which are expensive and have more adverse effects. Colistin and tigecycline are the currently available options for treatment of CRE infections. Carbapenem resistance in the enterobacteriaceae and other Gram-negative bacteria may be due to carbapenemase-mediated or noncarbapenemase-mediated mechanisms. In our review, we have compared different forms of carbapenem resistance and discussed issues related to susceptibility testing, treatment options, and subsequent clinical outcome.

Author Information

Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Correspondence to Mohammed Ali M. Marie, Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433, Kingdom of Saudi Arabia. Tel: +966 1 4696022; fax: +966 1 4693736; e-mail: dr.mmariali@gmail.com

Received 12 December, 2013

Revised 16 February, 2014

Accepted 16 February, 2014

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins