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Evaluation of diagnostic DNA microarray chips for viral pathogen

Yadav, Brijesh S.; Sharma, Bhaskar

Reviews in Medical Microbiology:
doi: 10.1097/MRM.0b013e328365c4ef
Review articles
Abstract

Pathogen identification plays a key role in the diagnosis, treatment and control of infections. Sequence-based techniques for identifying pathogens have appeared rapidly following the large-scale availability of genome nucleotide sequences. A DNA microarray is one such technique with multiplex properties in that they have the capability to screen all the known pathogens and also yet to be identified pathogens. The DNA microarray uses oligonucleotide probes, which are unique to a pathogen with respect to all other pathogens and nonpathogen genomes. Considering the importance of this technique, this article reviews microarray chips used for diagnosis of the viral pathogens and evaluates their performance and future prospects.

Author Information

Division of Biochemistry, Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.

Correspondence to Bhaskar Sharma, Division of Biochemistry, Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, Uttar Pradesh, India. E-mail: bhaskar@ivri.res.in

Received 17 May, 2013

Accepted 12 August, 2013

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins