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ACUTE RETINAL NECROSIS AND CYSTIC ENCEPHALOMALACIA IN A PREMATURE NEONATE

Wong, Ryan K. BA*; Khanifar, Aziz A. MD*; Sun, Grace MD*; Heier, Linda A. MD†; Saffra, Norman MD, FACS‡; Chan, R V. Paul MD, MS*

RETINAL Cases & Brief Reports: Spring 2010 - Volume 4 - Issue 2 - pp 202-205
doi: 10.1097/ICB.0b013e3181ad3900
Original Articles

Purpose: To report a case of an infant born at 30 weeks gestational age (GA) who, at 37 weeks GA, presented with bilateral acute retinal necrosis (ARN) syndrome and herpes simplex virus (HSV) encephalomalacia.

Methods: Observational case report.

Results: A premature infant was found to have ARN based on dilated funduscopic examination and positive HSV serologies. Herpes simplex virus encephalomalacia was diagnosed base on magnetic resonance imaging (MRI).

Conclusion: To our knowledge, this is the youngest reported patient with ARN. This case demonstrates that neonatal ARN may present with posterior chorioretinal lesions and highlights the importance of considering HSV infection of the central nervous system with MRI findings of cystic encephalomalacia.

The authors report a case of an infant born at 30 weeks gestational age who, at 37 weeks gestational age, presented with bilateral acute retinal necrosis syndrome and herpes simplex virus encephalomalacia. To the authors' knowledge, this is the youngest reported patient with acute retinal necrosis syndrome.

From the Departments of *Ophthalmology and †Radiology, Weill Cornell Medical College, New York, New York; and ‡Division of Ophthalmology, Maimonides Medical Center, Brooklyn, New York.

Supported by the St. Giles Foundation (RVPC).

None of the authors has any conflicts of interest to disclose.

Reprint requests: R.V. Paul Chan, MD, MS, Department of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, 11th Floor, Room Y 11.34, New York, NY 10021; e-mail: roc9013@med.cornell.edu

© 2010 Ophthalmic Communications Society, Inc.