Skip Navigation LinksHome > August 2014 - Volume 34 - Issue 8 > ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY OF CHORO...
Retina:
doi: 10.1097/IAE.0000000000000131
Original Study

ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY OF CHOROIDAL METASTASIS IN 14 EYES

Al-Dahmash, Saad A. MD; Shields, Carol L. MD; Kaliki, Swathi MD; Johnson, Timothy MD; Shields, Jerry A. MD

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Abstract

Purpose:

To describe the imaging features of choroidal metastasis using enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods:

This retrospective observational case series included 31 eyes with choroidal metastasis. Spectral domain EDI-OCT was performed using Heidelberg Spectralis HRA + OCT. The main outcome measures were imaging features by EDI-OCT.

Results:

Of 31 eyes with choroidal metastasis imaged with EDI-OCT, 14 (45%) eyes displayed image detail suitable for study. The metastasis originated from carcinoma of the breast (n = 7, 50%), lung (n = 5, 36%), pancreas (n = 1, 7%), and thyroid gland (n = 1, 7%). The mean tumor basal diameter was 6.4 mm, and mean thickness was 2.3 mm by B-scan ultrasonography. The tumor location was submacular in 6 (43%) eyes and extramacular in 8 (57%) eyes. By EDI-OCT, the mean tumor thickness was 987 μm. The most salient EDI-OCT features of the metastasis included anterior compression/obliteration of the overlying choriocapillaris (n = 13, 93%), an irregular (lumpy bumpy) anterior contour (n = 9, 64%), and posterior shadowing (n = 12, 86%). Overlying retinal pigment epithelial abnormalities were noted (n = 11, 78%). Outer retinal features included structural loss of the interdigitation of the cone outer segment tips (n = 9, 64%), the ellipsoid portion of photoreceptors (n = 8, 57%), external limiting membrane (n = 4, 29%), outer nuclear layer (n = 1, 7%), and outer plexiform layer (n = 1, 7%). The inner retinal layers (inner nuclear layer to nerve fiber layer) were normal. Subretinal fluid (n = 11, 79%), subretinal lipofuscin pigment (n = 1, 7%), and intraretinal edema (n = 2, 14%) were identified.

Conclusion:

The EDI-OCT of choroidal metastasis shows a characteristic lumpy bumpy anterior tumor surface and outer retinal layer disruption with preservation of inner retinal layers.

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