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ASSOCIATION OF PLASMA MALONDIALDEHYDE WITH ARMS2 GENETIC VARIANTS AND PHENOTYPES IN POLYPOIDAL CHOROIDAL VASCULOPATHY AND AGE-RELATED MACULAR DEGENERATION

Park, Dong Ho MD; Shin, Jae Pil MD; Kim, In Taek MD

doi: 10.1097/IAE.0000000000000047
Original Study

Purpose: To evaluate the relationships between plasma malondialdehyde (MDA) level and ARMS2 variants and phenotypes in patients with polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD).

Methods: This study is a retrospective case–control study. Plasma MDA was measured in 84 controls, 62 patients with PCV, and 42 patients with nAMD. Participants were genotyped for ARMS2 polymorphism. Phenotypes including bilaterality and greatest linear dimension based on fluorescein angiography (FA-GLD) and indocyanine green angiography (ICGA-GLD), were evaluated.

Results: Plasma MDA in the PCV and nAMD groups was higher than in the control group (P < 0.001, respectively). For ARMS2 variants, plasma MDA of homozygous high-risk genotype (TT) was higher than that of homozygous low-risk genotype (GG) in all groups (P < 0.001, respectively). Plasma MDA was higher in homozygous high-risk genotype than in heterozygous genotype in the control, PCV, and nAMD groups (P = 0.021, 0.002, and 0.004, respectively). In the nAMD group, there was a correlation between plasma MDA and both FA-GLD (r = 0.418, P = 0.006) and ICGA-GLD (r = 0.329, P = 0.033). There was a difference in plasma MDA between patients with unilateral and bilateral lesions in both PCV and nAMD (P = 0.017 and 0.019, respectively).

Conclusion: This study revealed significant relationships between the plasma MDA level and ARMS2 variants and phenotypes in PCV and nAMD.

This study revealed significant relationships between plasma malondialdehyde level and ARMS2 variants and phenotypes in polypoidal choroidal vasculopathy and age-related macular degeneration. These data could be added to the evidence linking oxidative stress to genotypic variants in polypoidal choroidal vasculopathy and neovascular age-related macular degeneration, and suggest a potential relationship between oxidative stress and phenotypes.

Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu, South Korea.

Reprint requests: Dong Ho Park, MD, Department of Ophthalmology, School of Medicine, Kyungpook National University, #50 Samduk-dong-2-ga, Jung-gu, Daegu 700-721, South Korea; e-mail: sarasate2222@gmail.com

Supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012004585) and by the Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A111345).

None of the authors have any conflicting interests to disclose.

© 2014 by Ophthalmic Communications Society, Inc.