Purpose: To measure choroidal thickness (CT) in children of various ages by using spectral optical coherence tomography with enhanced depth imaging and to investigate the association between subfoveal CT and ocular axial length, age, gender, weight, and height in children.
Methods: Healthy children were prospectively included between May and August 2012. Optical coherence tomography with the enhanced depth imaging system (Spectralis, Heidelberg, Germany) was used for choroidal imaging at nine defined points of the macula of both eyes. Axial length was measured using IOLMaster (Carl Zeiss Meditec, Dublin, CA). Height, weight, and refraction were recorded. Interobserver agreement in readings was also assessed by the Bland–Altman Method.
Results: Three hundred and forty-eight eyes from 174 children aged 3.5 years to 14.9 years were imaged. The mean subfoveal CT in right eyes was 341.96 ± 74.7 µm. Choroidal thickness increased with age (r = 0.24, P = 0.017), height, and weight but not with gender (P > 0.05). It was also inversely correlated to the axial length (r = 0.24, P = 0.001). The nasal choroid appeared thinner than in the temporal area (analysis of variance, P < 0.0001).
Conclusion: In children, CT increases with age and is inversely correlated to axial length. There is a significant variation of CT between children of the same age.
The measurement of choroidal thickness in children using optical coherence tomography is reliable. In the healthy pediatric population, the choroidal thickness increases with age, weight, and height and is inversely correlated to axial length. These findings could improve the understanding of vascular ocular diseases of childhood.
*Department of Ophthalmology, University Hospital of Besançon, Besançon, France;
†CHU Jean Minjoz, Besançon, France;
‡University of Franche-Comté, Besançon, France and
§Clinical Methodology Center, University Hospital of Besançon, Besançon, France.
Reprint requests: Maher Saleh, MD, PhD, Department of Ophthalmology, University Hospital of Besançon, 3 bd Fleming, 25030 Besançon, France; e-mail: firstname.lastname@example.org
None of the authors have any financial/conflicting interests to disclose.