Skip Navigation LinksHome > March 2014 - Volume 34 - Issue 3 > TREATMENT OF PERSISTENT SEROUS RETINAL DETACHMENT IN VOGT–KO...
Retina:
doi: 10.1097/IAE.0b013e3182a0e446
Original Study

TREATMENT OF PERSISTENT SEROUS RETINAL DETACHMENT IN VOGT–KOYANAGI–HARADA SYNDROME WITH INTRAVITREAL BEVACIZUMAB DURING THE SYSTEMIC STEROID TREATMENT

Reibaldi, Michele MD, PhD*; Russo, Andrea MD, PhD*; Avitabile, Teresio MD*; Uva, Maurizio G. MD*; Franco, Livio MD*; Longo, Antonio MD, PhD*; Toro, Mario D. MD*; Cennamo, Gilda MD, PhD; Mariotti, Cesare MD; Neri, Piergiorgio MD; Noci, Nicola D. MD§; Russo, Vincenzo MD, PhD§

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Abstract

Purpose:

To report the use of bevacizumab in patients with Vogt–Koyanagi–Harada disease and persistent serous retinal detachment during the systemic steroid treatment.

Methods:

Four patients with bilateral Vogt–Koyanagi–Harada disease with the resolution of ocular inflammation presenting a serous retinal detachment involving the fovea that persisted for at least 1 month, despite systemic corticosteroid treatment, received an intravitreal injection of bevacizumab during the steroid tapering stage. Best-corrected visual acuity, central retinal thickness, and macular sensitivity were evaluated.

Results:

Of 8 eyes, 7 (87%) had complete resolution of subretinal fluid within 1 month following the treatment. After the treatment, the mean best-corrected visual acuity and macular sensitivity improved significantly (P < 0.001, analysis of variance). Compared with baseline, at all measurements, central retinal thickness decreased significantly (P < 0.01, Tukey–Kramer test). At 6 months, a significant correlation was found between best-corrected visual acuity and macular sensitivity in the central 8° (linear regression, r = −0.73; P = 0.03), whereas no correlation was found between central retinal thickness and both best-corrected visual acuity and macular sensitivity.

Conclusion:

Intravitreal injection of bevacizumab during the corticosteroid therapy may be a treatment option for patients with decreased visual function because of persistent serous retinal detachment associated with Vogt–Koyanagi–Harada syndrome.

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