Purpose: To evaluate the effects of additional anti–vascular endothelial growth factor (VEGF) therapy for eyes with a retinal pigment epithelial (RPE) tear after anti-VEGF therapy and treated with additional anti-VEGF injections for recurrent or persistent exudative change.
Patients and Methods: Ten eyes (10 patients) followed up for >12 months after a recurrent RPE tear were evaluated retrospectively. The RPE tears on fundus autofluorescence images were measured and changes in the best-corrected visual acuity were evaluated.
Results: Patients were followed up for >12 months (mean, 27.3; range, 13–44 months). During 12 months of follow-up, additional anti-VEGF injections (mean, 3.3; range, 1–7) were administered. The mean size of the RPE tear at the onset was 6.5 mm2 (range, 1.3–16.3 mm2). At 12 months, the RPE tear increased in size >20% in 5 eyes and remained unchanged or decreased in the remaining half of eyes. The mean logarithm of the minimum angle of resolution best-corrected visual acuity was 0.43 at the time the RPE tear developed and 0.85 at 12 months. The RPE tear grade and age were prognostic factors for best-corrected visual acuity at 12 months.
Conclusion: Under continued anti-VEGF therapy, RPE tears may be stable in size and visual acuity could be maintained in some eyes; however, the visual acuity prognosis is still unsatisfactory in nonresponsive eyes.
Retinal pigment epithelial tears after anti&#x2013;vascular endothelial growth factor therapy may be stable in size, and visual acuity could be maintained with continuous anti&#x2013;vascular endothelial growth factor treatment, although the visual acuity prognosis is still unsatisfactory in nonresponsive eyes.
*Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan; and
†Department of Ophthalmology, Sumitomo Hospital, Osaka, Japan.
Reprint requests: Fumi Gomi, MD, Department of Ophthalmology, Osaka University Graduate School of Medicine, Room E7, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; e-mail: email@example.com
All patients provided the written informed consent for the treatment. The study adhered to the tenets of the Declaration of Helsinki.
None of the authors have any financial/conflicting interests to disclose.