Skip Navigation LinksHome > October 2013 - Volume 33 - Issue 9 > OUTER RETINAL TUBULATION IN DEGENERATIVE RETINAL DISORDERS
doi: 10.1097/IAE.0b013e318296b12f
Original Study


Goldberg, Naomi R. MD, PhD*,†; Greenberg, Jonathan P. MD; Laud, Ketan MD*; Tsang, Stephen MD, PhD; Freund, K. Bailey MD*,§

Collapse Box


Purpose: To demonstrate outer retinal tubulation (ORT) in various degenerative retinal disorders.

Methods: This was a retrospective review of the multimodal imaging of 29 eyes of 15 patients with various retinal dystrophies and inflammatory maculopathies manifesting ORT. The morphologic features of ORT and its evolution over time were analyzed using spectral-domain optical coherence tomography data.

Results: Outer retinal tubulation was identified as round or ovoid structures with hyperreflective borders in pattern dystrophy (six eyes), acute zonal occult outer retinopathy (five eyes), retinitis pigmentosa (four eyes), Stargardt disease (four eyes), gyrate atrophy (two eyes), choroideremia (two eyes), and various other degenerative conditions. These structures appeared to develop from the invagination of photoreceptors at the junction of intact and atrophic outer retina. During follow-up, the number and distribution of ORT largely remained stable. As zones of atrophy enlarged, the frequency of ORT appeared to increase. The ORT structures were found in <10% of patients with retinitis pigmentosa, Stargardt disease, or pattern dystrophy.

Conclusion: Outer retinal tubulation is found in various degenerative retinal disorders that share in common damage to the outer retina and/or retinal pigment epithelium. The presence of ORT may be an indicator of underlying disease stage and severity.

© 2013 by Ophthalmic Communications Society, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.