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Kang, Hae Min MD; Koh, Hyoung Jun MD

doi: 10.1097/IAE.0b013e318285cc24
Original Study

Purpose: To investigate factors associated with long-term recurrence of myopic choroidal neovascularization (CNV) after treatment with photodynamic therapy (PDT) and/or intravitreal antivascular endothelial growth factor injections.

Methods: Seventy-six eyes with myopic CNV completed at least a 48-month follow-up after treatments. The baseline characteristics of the eyes were compared, including age, gender, refractive errors, axial lengths, location of CNV, lacquer cracks, chorioretinal atrophy, dark rim, great linear dimension, and prior PDT.

Results: During mean follow-up of 71.21 ± 26.43 months, 35 eyes (46.1%) experienced at least 1 recurrence. Mean interval between initial treatment and first recurrence was 24.15 ± 18.10 months. Presence of lacquer crack (P = 0.022, χ2 test), absence of dark rim (P = 0.031, χ2 test), and prior PDT (P = 0.041, χ2 test) were significantly different between the eyes with and without recurrence. Among baseline characteristics, presence of lacquer crack (β = 1.272, P = 0.012) prior PDT (β = 1.607, P = 0.027), and absence of dark rim (β = −0.758, P = 0.020) were significantly associated with the recurrence of myopic CNV after treatment by multiple logistic regression.

Conclusion: Long-term follow-up revealed recurrence of myopic CNV in 46.1% of the patients after treatment. Presence of lacquer cracks, prior PDT, and absence of dark rim were risk factors for recurrence of myopic CNV.

In Brief

Long-term follow-up of myopic choroidal neovascularization after photodynamic therapy and/or anti-vascular endothelial growth factor therapy was 46.1% during 71 months. Presence of lacquer crack, absence of dark rim, and prior photodynamic therapy are risk factors for long-term recurrence of myopic choroidal neovascularization after treatment.

Author Information

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Reprint requests: Hyoung Jun Koh, MD, Department of Ophthalmology, Yonsei University College of Medicine, 134, Shinchon-dong, Seodaemoon-gu, Seoul 120-752, Korea; e-mail:

No authors have any financial/conflicting interests to disclose.

© 2013 by Ophthalmic Communications Society, Inc.