TRANS-TAMPONADE OPTICAL COHERENCE TOMOGRAPHY: Postoperative Imaging in Gas-Filled EyesEhlers, Justis P. MD*,†; Yuan, Alex MD, PhD*; Kaiser, Peter K. MD*,†; Dhoot, Dilsher MD*; Sears, Jonathan E. MD*; Martin, Daniel F. MD*,†; Singh, Rishi P. MD*,†; Srivastava, Sunil K. MD*,†Retina: June 2013 - Volume 33 - Issue 6 - p 1172–1178 doi: 10.1097/IAE.0b013e31827b6565 Original Studies Abstract In Brief Author Information Purpose: To investigate the feasibility of trans-tamponade optical coherence tomography and evaluate factors contributing to image quality and acquisition success. Methods: Retrospective case series of eyes receiving Postoperative Day 1 optical coherence tomography imaging after vitrectomy and gas tamponade. The quality of the scans was graded by three independent expert readers. Clinical and surgical variables were recorded and correlated with scan quality. Results: Eighty eyes were included in the study. An image quality classification scheme was developed (0–4, 0 = no image and 4 = comparable quality to trans-fluid optical coherence tomography). In 51 scans (64%), visualization of the inner retina and retinal pigment epithelium was achieved (Grades 2–4) but with variable image quality of the retinal layers. Twenty-nine scans (36%) achieved visualization of all retinal layers (Grades 3–4). Only 9 scans (11%) were of comparable quality to fluid-filled eyes (Grade 4). Pseudophakia (P = 0.0001), shorter operative times (P = 0.007), and macular surgery (P = 0.002) correlated with scan quality. An optimum scan protocol was developed to facilitate maximum quality images. Conclusion: Successful trans-tamponade optical coherence tomography through gas on Postoperative Day 1 is possible but significant variability exists in scan quality. The feasibility of obtaining high-quality Postoperative Day 1 macular visualization with trans-tamponade spectral domain optical coherence tomography in eyes filled with gas was evaluated. Twenty-nine of 80 eyes (36%) revealed high-resolution trans-tamponade scans that definitively demonstrated inner and outer retinal architecture using the Cirrus spectral domain optical coherence tomography. *Vitreoretinal Service †Ophthalmic Imaging Center, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio. Reprint requests: Justis P. Ehlers, MD, Ophthalmic Imaging Center, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue/i32, Cleveland, OH 44195; e-mail: firstname.lastname@example.org This work was funded by unrestricted grant from the Research to Prevent Blindness. The other authors have no conflicts of interest to disclose. Carl Zeiss Meditec (P.K.K.). © 2013 by Ophthalmic Communications Society, Inc.