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Retina:
doi: 10.1097/IAE.0b013e3182794b06
Original Studies

RESPONSE OF RETINAL SENSITIVITY TO RANIBIZUMAB TREATMENT OF MACULAR EDEMA AFTER ACUTE BRANCH RETINAL VEIN OCCLUSION

Mylonas, Georgios MD; Sacu, Stefan MD; Dunavoelgyi, Roman MD; Matt, Gerlinde MD; Blum, Robert MD; Buehl, Wolf MD; Pruente, Christan MD; Schmidt-Erfurth, Ursula MD

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Abstract

Purpose:

To evaluate microperimetry changes in patients with acute macular edema secondary to branch retinal vein occlusion during a follow-up period of 12 months with intravitreal ranibizumab treatment (Lucentis; Novartis).

Methods:

Patients with macular edema secondary to branch retinal vein occlusion received an intravitreous injection of 0.5 mg of ranibizumab (0.05 mL). Best-corrected visual acuity, Spectralis OCT (Heidelberg Engineering), and color fundus photography were performed at monthly intervals over a follow-up period of 1 year. Macular function was documented by microperimetry (Nidek, MP-1) at baseline, 3, and 12 months.

Results:

Data of 20 patients without lack of microperimetry results were included to the statistical analyses. The size of the area of absolute scotoma was reduced from 16% at baseline to 11.7% at Month 3 and remained stable in the entire study duration (P > 0.05). Mean differential light threshold improved significantly under therapy from 9.47 dB at baseline to 12.53 dB at 12 months (P < 0.001). Best-corrected visual acuity correlated significantly with central millimeter thickness and mean retinal sensitivity at baseline and at 12-month follow-up visits.

Conclusion:

In addition to anatomical restoration and increased visual acuity, intravitreal ranibizumab also improved the central macular function in patients with acute macular edema after branch retinal vein occlusion.

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