Skip Navigation LinksHome > June 2013 - Volume 33 - Issue 6 > RECALCITRANT MACULAR EDEMA AFTER INTRAVITREAL BEVACIZUMAB IS...
Retina:
doi: 10.1097/IAE.0b013e31827c53a0
Original Studies

RECALCITRANT MACULAR EDEMA AFTER INTRAVITREAL BEVACIZUMAB IS RESPONSIVE TO AN INTRAVITREAL DEXAMETHASONE IMPLANT IN RETINAL VEIN OCCLUSION

Sharareh, Behnam BS*,†; Gallemore, Ron MD, PhD*; Taban, Mehran MD*; Onishi, Spencer BS*; Wallsh, Josh BS*

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Abstract

Purpose:

To test the efficacy of an intravitreal dexamethasone implant in patients with recalcitrant macular edema secondary to retinal vein occlusion.

Methods:

A retrospective chart review was performed for 18 patients with retinal vein occlusion who received multiple bevacizumab intravitreal injections before treatment with an intravitreal dexamethasone implant.

Results:

Two subgroups of bevacizumab-resistant patients were identified. Both subgroups responded to subsequent treatment with an intravitreal dexamethasone implant with an average reduction in central foveal thickness of 146.8 ± 33.65 μm. A visual acuity improvement of 0.26 ± 0.07 (logarithm of minimal angle of resolution) was also noted. Intraocular pressure increased by an average of 3.33 ± 0.66 mmHg and was managed by 1.0 ± 0.5 topical drops.

Conclusion:

A subset of patients do not have resolution of macular edema after treatment with intravitreal bevacizumab. Such patients may respond to treatment with an intravitreal dexamethasone implant.

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