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EFFICACY OF VITRECTOMY WITH TRIAMCINOLONE ASSISTANCE VERSUS INTERNAL LIMITING MEMBRANE PEELING FOR HIGHLY MYOPIC MACULAR HOLE RETINAL DETACHMENT

Wei, Yong MD*; Wang, Ningli MD; Zu, Zhongqiao MD*; Bi, Chuncao MD*; Wang, Huaizhou MD; Chen, Fenghua MD; Yang, Xingguang MD*

doi: 10.1097/IAE.0b013e31827b6422
Original Studies

Purpose: To compare the outcomes of pars plana vitrectomy (PPV) with or without the adjuvant surgical procedures: triamcinolone acetonide (TA) assistance and/or internal limiting membrane (ILM) peeling for the treatment of highly myopic macular hole retinal detachment (MHRD).

Design: Case–control study.

Methods: Pars plana vitrectomy combined with 2 kinds of adjuvant surgical procedures were used on 96 highly myopic eyes with MHRD. These eyes were assigned to 4 groups randomly: Group 1, non–TA-assisted PPV and without ILM peeling; Group 2, non–TA-assisted PPV with ILM peeling; Group 3, TA-assisted PPV and without ILM peeling; Group 4, TA-assisted PPV with ILM peeling. Anatomical reattachment of the retina, macular hole closure, and best-corrected visual acuity were measured.

Results: The rates of both retinal reattachment and macular hole closure were higher in Group 2 (84.0 and 44.0%) and Group 3 (80.8 and 46.2%) than Group 1 (73.9 and 17.4%); however, there were no differences between Group 2 and Group 3 (P > 0.05). The rates of macular hole closure were extremely low in Group 1 and also in eyes with extreme long axial lengths (≥29.0 mm), “severe” chorioretinal atrophy, and posterior staphyloma.

Conclusion: Pars plana vitrectomy with either TA assistance or ILM peeling was effective for the treatment of highly myopic MHRD. If you peel the ILM, adding TA does not affect closure rates; and if TA is used to visualize the vitreous, ILM peeling may not be necessary in MHRD. There was a lower anatomical success rate in MHRD with extreme long axial lengths, severe chorioretinal atrophy, and posterior staphyloma.

Pars plana vitrectomy with either triamcinolone acetonide (TA) assistance or internal limiting membrane (ILM) peeling was effective for the treatment of highly myopic macular hole retinal detachment (MHRD). If you peel the ILM, adding TA does not affect closure rates; and if TA is used to visualize the vitreous, ILM peeling may not be necessary in MHRD. There was a lower anatomical success rate in MHRD with extreme long axial lengths, “severe” chorioretinal atrophy, and posterior staphyloma.

*Shaanxi Ophthalmic Medical Center, Xi’an No.4 Hospital, Affiliated Guangren Hospital, School of Medicine, Xi'an Jiaotong, University, Xi’an, China

Beijing Tongren Eye Center, Beijing Tongren Hospital, Ophthalmology and Visual Science Key Laboratory, Beijing Ophthalmology School, Capital Medical University, Beijing, China.

Reprint requests: Yong Wei, MD, Department of Ophthalmology, Xi'an NO.4 Hospital, #21 JieFang road, Xi’an 710004, China; e-mail: weiyongdoctor@163.com

Supported in part by a grant from Society Development, Medicine Research Foundation, funded by the Xi’an city government (SF1022[5]).

The authors declare no conflict of interest.

Y. Wei and N. Wang contributed equally to this work.

© 2013 by Ophthalmic Communications Society, Inc.