Skip Navigation LinksHome > April 2013 - Volume 33 - Issue 4 > ANALYSIS OF THE MOLECULAR BIOLOGIC MILIEU OF THE VITREOUS IN...
Retina:
doi: 10.1097/IAE.0b013e31826d350a
Original Study

ANALYSIS OF THE MOLECULAR BIOLOGIC MILIEU OF THE VITREOUS IN PROLIFERATIVE VITREORETINOPATHY

Wladis, Edward J. MD, FACS*; Falk, Naomi S. MD, OD; Iglesias, Bibiana V. BA; Beer, Paul M. MD; Gosselin, Edmund J. PhD

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Abstract

Purpose: Previous investigations have explored molecular differences between proliferative vitreoretinopathy and primary retinal detachment. An exploration of a greater number of molecules might provide novel insight into the biology of this disorder and identify potential therapeutic targets.

Methods: Vitreous specimens were obtained from patients with epiretinal membranes or macular puckers (n = 15), patients with a primary retinal detachment without proliferative vitreoretinopathy (n = 15), and patients with retinal detachments and proliferative vitreoretinopathy (n = 15). A multiplex assay was performed to calculate the concentrations of 48 different cytokines and chemokines, and statistical analyses were performed to identify differences between the groups.

Results: Of the 48 molecules that were studied, we identified 10 that were statistically significantly different in cases of proliferative vitreoretinopathy, including interleukins 4, 5, 6, and 15; granulocyte–macrophage colony-stimulating factors; stem cell factor; stem cell growth factor; macrophage inflammatory protein 1α; and interferon γ–induced protein 10.

Conclusion: Proliferative vitreoretinopathy represents a highly ordered molecular process that involves discrete changes in the concentrations of specific cytokines and chemokines. These molecules may represent novel therapeutic targets.

© The Ophthalmic Communications Society, Inc.

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