Skip Navigation LinksHome > June 2012 - Volume 32 - Issue 6 > NEW INSIGHTS INTO THE PATHOANATOMY OF DIABETIC MACULAR EDEMA...
doi: 10.1097/IAE.0b013e3182349686
Original Studies

NEW INSIGHTS INTO THE PATHOANATOMY OF DIABETIC MACULAR EDEMA: Angiographic Patterns and Optical Coherence Tomography

Byeon, Suk Ho MD*; Chu, Young Kwang MD; Hong, Young Taek MD*; Kim, Min MD*; Kang, Hae Min MD*; Kwon, Oh Woong MD*

Supplemental Author Material
Collapse Box


Purpose: To describe the pathoanatomy of diabetic macular edema in optical coherence tomography and its correlation with fluorescein angiography patterns.

Methods: Sixty eyes of 56 patients were analyzed. Diabetic macular edema was classified into typical focal leakage (from microaneurysm), typical diffuse leakage (the capillary plexus), or combined/questionable leakage using fluorescein angiography and retinal thickness profiles. The leakage and pooling patterns in fluorescein angiography were matched to the corresponding optical coherence tomography images and analyzed.

Results: Focal leakage shows swelling predominantly in the outer plexiform layer (OPL). Deeply located microaneurysms directly leak into the loose fiber portion of OPL (Henle layer) through the “fluid conductivity barrier” (synaptic portion of OPL). Diffuse leakage caused swelling predominantly in the inner nuclear layer and secondarily in the OPL. The deep capillary plexus is located between the two “fluid barriers” (inner plexiform layer and OPL); thus, diffuse leakage is primarily related with swelling in the inner nuclear layer. In the combined/questionable leakage, partial sections consisting of inner nuclear layer swelling and much larger areas of OPL/outer nuclear layer swelling are noticed.

Conclusion: Based on the concept of the fluid conductivity barrier, we revealed a correlation between the intraretinal location of the leakage source and where the fluid accumulated within the retinal layers.

© The Ophthalmic Communications Society, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.