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Unilateral Acute Idiopathic Maculopathy

Yannuzzi, Lawrence A. MD; Jampol, Lee M. MD; Rabb, Maurice F. MD; Sorenson, John A. MD; Beyrer, Charles MD; Wilcox, Lloyd M. Jr MD

doi: 10.1097/IAE.0b013e31823f9afa
Reprint Article

This is a report of nine patients who experienced sudden, severe, unilateral central vision loss following a flulike illness. Each patient had an exudative detachment of the macula. All patients experienced a spontaneous resolution of the acute macular manifestations with near-complete recovery of vision. A characteristic bull's-eye appearance in the macula persisted. The acute manifestations of the disorder did not recur in any of the patients during the period of follow-up. The constellation of findings was suggestive of an inflammatory disease of the retinal pigment epithelium, but a specific causative agent could not be identified. The acute clinical and angiographic features, the natural course, and the residual pigment epithelial derangement were not consistent with any previously described disorder.

LuEsther T. Mertz Retinal Research Laboratory, Manhattan Eye, Ear and Throat Hospital (Drs Yannuzzi and Sorenson), The Macula Foundation, Inc (Drs Yannuzzi and Sorenson), and Columbia University School of Medicine (Drs Yannuzzi and Sorenson), New York, NY; Department of Ophthalmology, Northwestern University Medical School, Chicago, 111 (Dr Jampol): Department of Ophthalmology and Visual Sciences. Eye and Ear Infirmary, UIC Eye Center, University of Illinois at Chicago (Dr Rabb); Stony Brook (NY) University (Dr Beyrer); Southside Hospital, Bayshore, NY (Dr Beyrer); Concord (NH) Hospital (Dr Wilcox); Veterans Administration Hospital, Boston, Mass (Dr Wilcox); and Cornell University Medical College, New York (Dr Wilcox).

Reprint requests to Manhattan Eye, Ear and Throat Hospital, 210 E 64th St, New York, NY 10021 (Dr Yannuzzi).

Dennis Orlock, COP, provided photographic support; Jay Prensky, MD, Andrew Henrich, MD. and Andrew Packer, MD, referred patients 5, 3, and 9, respectively; and Barry Lipson, MD, assisted in preparing the manuscript.

Accepted May 12, 1991

© The Ophthalmic Communications Society, Inc.