Stereoscopic transparencies studied with magnification and projection suggest that the retinal elevation that communicates with optic pits is frequently a schisislike separation of the internal layers of retina. Thirteen of 15 eyes with optic pits and maculopathy fit the schisis pattern. Separation of the outer layers of the retina is a secondary phenomenon that starts in the macula.
Departments of Ophthalmology, New York Hospital-Cornell Medical Center (Drs Lincoff and Lopez); Universitats-Augenklinik, Tubingen, West Germany (Dr Kreissig); The Manhattan Eye, Ear, and Throat Hospital, New York (Dr Yannuzzi); Michigan State University, East Lansing (Dr Cox); and The Medical College of Wisconsin, Milwaukee (Dr Burton).
Reprint requests to The New York Hospital, 525 E 68th St, New York, NY 10021 (Dr Lincoff).
Read in part before the Fluorescein Angiography Club, New Orleans, Nov 8,1986, and in full as the Paul Cibis Lecture before the Seventh Biennial Meeting of the Cibis Club, Montreal, June 12, 1987.
This study was supported by private grants from Edward Grayson and The Bostwick Fund, New York.
Frederick Jakobiec, MD, William Havener, MD, and Lawrence Singerman, MD, reviewed the manuscript and made suggestions. Dr Singerman also referred patient 12. Jeffrey Shakin, MD, referred patient 14, and Harold Weissman, MD, referred patient 15.
Accepted August 31, 1987