Skip Navigation LinksHome > January/March 2013 - Volume 28 - Issue 1 > Influence of aging on the skin quality of white-skinned wome...
Revista Brasileira de Cirurgia Plastica:
doi: 20130100.0-00008
Original Article

Influence of aging on the skin quality of white-skinned women: the role of collagen, elastic material density, and vascularization

Ortolan, Morgana Cláudia Aparecida Bergamo1; de Lourdes Pessole Biondo-Simões, Maria2; do Rocio Valenga Baroni, Eloina3; Auersvald, André4; Auersvald, Luiz Augusto5; Netto, Mário Rodrigues Montemor6; Biondo-Simões, Rachel7

Collapse Box

Abstract

Background: : In the present study, we aimed to evaluate the influence of aging on the skin quality of white-skinned women by assessing collagen levels, elastic material density, and vascularization.

Methods: : Histological and morphometric analyses were performed on 218 preauricular skin fragments from white-skinned women who underwent facial cosmetic surgery. Anti-CD34 was used to identify the blood vessels, Weigert's staining was used to visualize elastic fibers, and Picro-sirius Ultra Red staining was employed for analyzing and quantifying the expression of type I, III, and total collagen. Data were analyzed according to the following donor age groups: < 40, 40-49, 50-59, 60-69, and > 70 years.

Results: Fragmentation and disorganization of collagen fibers were observed in certain samples, particularly in samples from patients aged > 60 years. Significant differences between age and the thickness of the dermis and epidermis were not detected. However, a relationship was identified between age and the percentages of type I, III, and total collagen, and an increase of elastic fibers density was associated with age progression (P < 0.001). The comparison of the skin of patients with a decade difference in age did not reveal a significant difference in the elastic material quality; however, when the age difference was of 2 decades or more, there was a significant difference in elastic fibers (P < 0.05). The difference in the number of blood vessels between the groups was not significant (P = 0.112).

Conclusions: Aging promoted collagen reduction, fiber degradation and fragmentation, and increased disorganized elastic material density; however, it did not affect the number of dermal blood vessels.

© 2013 Sociedade Brasileira de Cirurgia Plastica

You currently do not have access to this article.

You may need to:

Note: If your society membership provides for full-access to this article, you may need to login on your society’s web site first.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.