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The Buffering Effect of Social Support on Hypothalamic-Pituitary-Adrenal Axis Function During Pregnancy

Giesbrecht, Gerald F. PhD; Poole, Julia C. BA; Letourneau, Nicole PhD; Campbell, Tavis PhD; Kaplan, Bonnie J. PhD; the APrON Study Team

Psychosomatic Medicine:
doi: 10.1097/PSY.0000000000000004
Original Articles
Abstract

Objective: Recent studies suggest that effective social support during pregnancy may buffer adverse effects of maternal psychological distress on fetal development. The mechanisms whereby social support confers this protective advantage, however, remain to be clarified. The aim of this study was to assess whether individual differences in social support alter the covariation of psychological distress and cortisol during pregnancy.

Methods: Eighty-two pregnant women’s psychological distress and cortisol were prospectively assessed in all three trimesters using an ecological momentary assessment strategy. Appraisal of partner social support was assessed in each trimester via the Social Support Effectiveness questionnaire.

Results: In multilevel analysis, ambulatory assessments of psychological distress during pregnancy were associated with elevated cortisol levels (unstandardized β = .023, p < .001). Consistent with the stress-buffering hypothesis, social support moderated the association between psychological distress and cortisol (unstandardized β = −.001, p = .039), such that the covariation of psychological distress and cortisol increased with decreases in effective social support. The effect of social support for women with the most effective social support was a 50.4% reduction in the mean effect of distress on cortisol and a 2.3-fold increase in this effect for women with the least effective social support scores.

Conclusions: Pregnant women receiving inadequate social support secrete higher levels of cortisol in response to psychological distress as compared with women receiving effective social support. Social support during pregnancy may be beneficial because it decreases biological sensitivity to psychological distress, potentially shielding the fetus from the harmful effects of stress-related increases in cortisol.

Author Information

From the Department of Paediatrics, (G.F.G., J.C.P., N.L., B.J.K.), Faculty of Medicine, University of Calgary, Behavioural Research Unit, Alberta Children’s Hospital, Calgary, Alberta, Canada; Faculties of Nursing (N.L.) and Department of Psychology (T.C.), University of Calgary, Calgary, Alberta, Canada.

Address correspondence and reprint requests to Gerald F. Giesbrecht, PhD, Department of Paediatrics, Faculty of Medicine, University of Calgary, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8. E-mail: ggiesbre@ucalgary.ca

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.psychosomaticmedicine.org).

Received for publication January 8, 2013; revision received August 10, 2013.

Copyright © 2013 by American Psychosomatic Society

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