Objective: Prior research suggesting a relationship between pancreatic cancer and depression conducted on clinical populations has been subject to recall bias. We reexamined this association using longitudinal population-based data.
Methods: This was a retrospective cohort study using longitudinal insurance claims data.
Results: Men with mental disorders were more likely to develop pancreatic cancer than those without psychiatric claims (odds ratio 2.4, confidence interval 1.15–4.78). Depression more commonly preceded pancreatic cancer than it did other gastrointestinal malignancies (odds ratio 4.6, confidence interval 1.07–19.4) or all other cancers (odds ratio 4.1, confidence interval 1.05–16.0).
Conclusions: Depression and pancreatic cancer are associated in the general population.